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Hormonal imbalance and disturbances in carbohydrate metabolism associated with chronic feeding of high sucrose low magnesium diet in weanling male wistar rats

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Abstract

This study was designed to determine chronic effect of high sucrose low magnesium (HSLM) diet in weanling rats on plasma thyroid profile, catecholamines and activities of key hepatic glycolytic, and gluconeogenic enzymes. Compared to control diet fed group, significantly elevated levels of plasma triiodothyronine, tetraiodothyronine, catecholamines (epinephrine, norepinephrine, and dopamine) and activity of hepatic glycolytic (hexokinase and glucokinase), and gluconeogenic (glucose-6-phosphatase) enzymes were observed in high sucrose and low magnesium fed groups. However, HSLM diet had an additive effect on all these three parameters. The study thus, assumes significance as it shows that hormonal imbalance and disorders in carbohydrate metabolism at an early stage of development can be due to dietary modification or due to deficiency of key element magnesium.

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Acknowledgments

The authors are grateful to UGC and CSIR, New Delhi, India for providing financial assistance for carrying out this research work.

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  1. Department of Biochemistry, Panjab University, Chandigarh, 160014, India

    Meenakshi Garg, Pranav Mehra & Devi Dayal Bansal

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  1. Meenakshi Garg
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  2. Pranav Mehra
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Correspondence to Devi Dayal Bansal.

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Garg, M., Mehra, P. & Bansal, D.D. Hormonal imbalance and disturbances in carbohydrate metabolism associated with chronic feeding of high sucrose low magnesium diet in weanling male wistar rats. Mol Cell Biochem 389, 35–41 (2014). https://doi.org/10.1007/s11010-013-1924-z

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  • DOI: https://doi.org/10.1007/s11010-013-1924-z

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