Molecular and Cellular Biochemistry

, Volume 388, Issue 1–2, pp 211–218 | Cite as

miR-141 suppresses proliferation and motility of gastric cancer cells by targeting HDGF

  • Bitao Chen
  • Tao Huang
  • Jun Jiang
  • Lei Lv
  • Hongxing Li
  • Shitao Xia
Article

Abstract

miR-141 belongs to the miR-200 family, and has been found to be associated with numerous human malignancies; however, its role in gastric cancer (GC) has not been examined in detail. Here, we validated that miR-141 was decreased in GC tissues and cell lines. Forced expression of miR-141 significantly repressed GC cell proliferation and colony formation. Furthermore, miR-141 suppressed in vitro migration and invasion of GC cells. Hepatoma-derived growth factor (HDGF) was confirmed to be a direct target of miR-141 in GC cells. The suppressive effects of miR-141 on GC cell proliferation, colony formation, in vitro migration, and invasion were partially mediated by suppressing HDGF expression. Moreover, the expression of HDGF was negatively correlated with miR-141 in GC tissues. Our data suggest that miR-141 might be associated and plays essential role in GC progression.

Keywords

miR-141 Gastric cancer HDGF Proliferation Migration Invasion 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Bitao Chen
    • 1
  • Tao Huang
    • 2
  • Jun Jiang
    • 3
  • Lei Lv
    • 2
  • Hongxing Li
    • 1
  • Shitao Xia
    • 1
  1. 1.Department of GastroenterologyThe No.1 People’s Hospital of JingmenJingmenChina
  2. 2.Department of UrologyWuhan No,1 Hospital, Huazhong University of Science and TechnologyWuhanChina
  3. 3.Department of OncologyThe Central Hospital of WuhanWuhanChina

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