Inhibition of miR-92b suppresses nonsmall cell lung cancer cells growth and motility by targeting RECK
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microRNAs play critical roles in the progression and metastasis of nonsmall cell lung cancer (NSCLC). miR-92b acts as an oncogene in some malignancies; however, its role in NSCLC remains poorly understood. Here, we found that miR-92b was significantly increased in human NSCLC tissues and cell lines. Inhibition of miR-92b remarkably suppressed cell proliferation, migration, and invasion of NSCLC cells. Reversion-inducing-cysteine-rich protein with kazal motifs (RECK) was identified to be a target of miR-92b. Expression of miR-92b was negatively correlated with RECK in NSCLC tissues. Collectively, miR-92b might promote NSCLC cell growth and motility partially by inhibiting RECK.
KeywordsmiR-92 Nonsmall cell lung cancer Growth Migration Invasion
This work was supported by Key Natural Science Foundation of Hubei Province (No. 2011CDA065)
Conflict of interest
We declare that we have no conflict of interest.
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