Molecular and Cellular Biochemistry

, Volume 385, Issue 1–2, pp 207–213 | Cite as

miR-25 promotes gastric cancer cells growth and motility by targeting RECK

  • Hongying Zhao
  • Yu Wang
  • Liu Yang
  • Rongke Jiang
  • Wenqing Li
Article

Abstract

Gastric cancer (GC) is the second leading cause of cancer-related death worldwide. Recently, accumulating evidence suggests that microRNAs (miRNAs) play prominent roles in tumorigenesis and metastasis. Here, we confirmed that miR-25 was significantly increased in human GC tissues and cell lines. Forced expression of miR-25 remarkably enhanced cell proliferation, migration, and invasion in GC cells, whereas inhibition of miR-25 by inhibitor caused significant suppression of proliferation and significant increase of apoptosis. Moreover, inhibition of miR-25 significantly decreased migration and invasion of GC cells. Finally, reversion-inducing-cysteine-rich protein with kazal motifs (RECK) was found to be a target of miR-25. Overexpression of RECK could significantly reverse the oncogenic effect of miR-25. Taken together, miR-25 might promote GC cells growth and motility partially by targeting RECK.

Keywords

miR-25 RECK Gastric cancer Proliferation Migration Invasion 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Hongying Zhao
    • 1
  • Yu Wang
    • 1
  • Liu Yang
    • 1
  • Rongke Jiang
    • 1
  • Wenqing Li
    • 1
  1. 1.Department of Oncology, 5th Affiliated Hospital of Qiqihar Medical CollegeDaqing LongNan HospitalDaqingChina

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