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Growth and sex effects on the expression of syndecan-4 and glypican-1 in turkey myogenic satellite cell populations

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Abstract

The adult skeletal muscle stem cells, satellite cells, are responsible for skeletal muscle growth and regeneration. Satellite cells represent a heterogeneous cell population that differentially express cell surface markers. The membrane-associated heparan sulfate proteoglycans, syndecan-4, and glypican-1, are differentially expressed by satellite cells during the proliferation and differentiation stages of satellite cells. However, how the population of syndecan-4- or glypican-1-positive satellite cells changes during proliferation and differentiation, and how sex and muscle growth potential affect the expression of these genes is unknown. Differences in the amount of satellite cells positive for syndecan-4 or glypican-1 would affect the process of proliferation and differentiation which would impact both muscle mass accretion and the regeneration of muscle. In the current study, the percentage of satellite cells positive for syndecan-4 or glypican-1 from male and female turkeys from a Randombred Control Line 2 and a line (F) selected for increased 16-week body weight were measured during proliferation and differentiation. Growth selection altered the population of syndecan-4- and glypican-1-positive satellite cells and there were sex differences in the percentage of syndecan-4- and glypican-1-positive satellite cells. This study provides new information on dynamic changes in syndecan-4- and glypican-1-positive satellite cells showing that they are differentially expressed during myogenesis and growth selection and sex affects their expression.

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Acknowledgments

Salary and partial research support to S.G.V. provided by state and federal funds appropriated to the Ohio Agricultural Research and Development Center, The Ohio State University, the National Institute of Food and Agriculture Multistate Project NC-1184 to S.G.V. and D.C.M., and the National Research Initiative Competitive Grant No. 2009-35503-05176 to S.G.V. from the USDA National Institute of Food and Agriculture are acknowledged.

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Authors and Affiliations

  1. Department of Animal Sciences, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH, 44691, USA

    Yan Song & Sandra G. Velleman

  2. Department of Animal Science, South Dakota State University, Brookings, SD, 57007, USA

    Douglas C. McFarland

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  1. Yan Song
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  2. Douglas C. McFarland
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Correspondence to Sandra G. Velleman.

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Song, Y., McFarland, D.C. & Velleman, S.G. Growth and sex effects on the expression of syndecan-4 and glypican-1 in turkey myogenic satellite cell populations. Mol Cell Biochem 378, 65–72 (2013). https://doi.org/10.1007/s11010-013-1594-x

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  • DOI: https://doi.org/10.1007/s11010-013-1594-x

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