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Impact of XPD gene polymorphism on risk of prostate cancer on north Indian population

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Abstract

Prostate cancer is the second most diagnosed cancer in men next to skin cancer in the developed world. Risk of disease varies most prominently with age, ethnicity, family history, and diet. Genetic polymorphism of some genes has been implicated in increasing the risk. The XPD (Xeroderma pigmentosum group D) gene codes for a DNA helicase involved in transcription and nucleotide excision repair. The aim of this study is to evaluate the effect of XPD 751 Lys/Gln polymorphism on risk of prostate cancer on north Indian patients. Blood sample from 150 prostate cancer patients, 150 from Prostate Hyper Plasia and equal number of samples from healthy control groups was collected from North India. The polymerase chain reaction and restrictive fragment length polymorphism techniques were implemented. Statistically non-significant increase risk of prostate cancer was observed with patients having Gln/Gln genotype (OR 1.62, 95% CI).

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Acknowledgments

The authors of this article are grateful for the clinical staff at the Department of Urology in postgraduate education and medical research, Chandigarh, India, for the kind assistant provided during sample collections.

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Authors and Affiliations

  1. Department of Biotechnology, Panjab University, 160014, Chandigarh, India

    Ranbir Chander Sobti, Salih Abdul Mahdi, Libsy Gupta, Hitender Thakur & Neha Singh

  2. Department of Biotechnology, University of Gondar, Gondar, Ethiopia

    Nega Berhane

  3. Department of Mathematics, University of Gondar, Gondar, Ethiopia

    Shiferaw Melese

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  1. Ranbir Chander Sobti
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  2. Nega Berhane
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  3. Shiferaw Melese
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  4. Salih Abdul Mahdi
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Correspondence to Ranbir Chander Sobti.

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Sobti, R.C., Berhane, N., Melese, S. et al. Impact of XPD gene polymorphism on risk of prostate cancer on north Indian population. Mol Cell Biochem 362, 263–268 (2012). https://doi.org/10.1007/s11010-011-1152-3

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  • DOI: https://doi.org/10.1007/s11010-011-1152-3

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