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Mammalian cell entry gene family of Mycobacterium tuberculosis

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Abstract

Knowledge of virulence factors is important to understand the microbial pathogenesis and find better antibiotics. Mammalian cell entry (mce) is a crucial protein family for the virulence of Mycobacterium tuberculosis (M. tuberculosis). This review summarized the advances on mce genes. The genomic organization, characteristics of mce genes, phylogeny of this family, and their roles in M. tuberculosis virulence are emphasized in this review.

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Abbreviations

HIV:

Human immunodeficiency virus

SBP:

Substrate-binding proteins

ABC:

ATP-binding cassette

CHP:

Conserved hypothetical protein

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Acknowledgments

The work is Supported by the National key infectious disease project (No. 2008ZX10003-006, No. 2008ZX10003-001), national natural science foundation (No. 81071316), Excellent PhD thesis fellowship of southwest university (No. kb2009010, No. ky2009009), The Fundamental Research Funds for the Central Universities (XDJK2009A003) and Natural Science Foundation Project of CQ CSTC (CSTC, 2010BB5002).

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  1. State Key Laboratory Breeding Base of Eco-Enviroment and Bio-Resource of the Three Gorges Area, Institute of Modern Biopharmaceuticals, School of Life Sciences, Southwest University, Chongqing, China

    Fan Zhang & Jian-Ping Xie

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  1. Fan Zhang
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Correspondence to Jian-Ping Xie.

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Zhang, F., Xie, JP. Mammalian cell entry gene family of Mycobacterium tuberculosis . Mol Cell Biochem 352, 1–10 (2011). https://doi.org/10.1007/s11010-011-0733-5

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