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The ENPP1 K121Q polymorphism is not associated with type 2 diabetes and related metabolic traits in an Iranian population

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Abstract

The K121Q polymorphism of the ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) gene has been variably associated with insulin resistance and type 2 diabetes (T2D) in several populations. However, this association has not been studied in Iranian subjects and we hypothesized that the K121Q variant might be associated with T2D and related metabolic traits in this population. The K121Q genotypes were determined by PCR-restriction fragment length polymorphism in 377 normoglycemic controls and 155 T2D patients. T2D patients had significantly higher values for systolic and diastolic blood pressure, BMI, glucose, cholesterol, triglyceride, LDL, apoB, insulin, and HOMA-IR, and lower levels of HDL than the normoglycemic subjects. The frequency of the Q allele did not differ between T2D and normoglycemic subjects (OR 0.96, 95% CI 0.90–2.00, P = 0.70). The Q allele frequency was 16.5% in T2D and 15.2% in normoglycemic subjects. The ENPP1 genotype (KQ + QQ) was not associated with the systolic and diastolic blood pressure, glucose, triglyceride, cholesterol, LDL-C and HDL-C, apo B, BMI, HOMA-IR, and insulin levels in both normoglycemic and T2D groups. Our results suggest that the ENPP1 121Q allele might not be associated with T2D and related metabolic traits among Iranian subjects.

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Authors and Affiliations

  1. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Islamic Republic of Iran

    Hamzeh Saberi

  2. Department of Clinical Biochemistry, Faculty of Medicine, Ahwaz Jundi-Shapour University of Medical Sciences, Ahwaz, Islamic Republic of Iran

    Narges Mohammadtaghvaei

  3. Biomedical Laboratory, Women Research Center, Al-Zahra University, Tehran, Islamic Republic of Iran

    Shekufeh Gulkho

  4. Department of Clinical Biochemistry, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran

    Salar Bakhtiyari

  5. Department of Biology, Faculty of Science, Shahid Chamran University, Ahwaz, Islamic Republic of Iran

    Mohammad Mohammadi

  6. Department of Biology, Faculty of Basic Sciences, Alzahra University, Tehran, Islamic Republic of Iran

    Parichehr Hanachi

  7. Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran

    Siavash Gerayesh-nejad & Reza Meshkani

  8. Department of Biochemistry and Genetic, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Islamic Republic of Iran

    Mehryar Zargari

  9. Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Islamic Republic of Iran

    Farangis Ataei

  10. Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Islamic Republic of Iran

    Leila Parvaneh

  11. Endocrinology and Metabolism Research Centre, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran

    Bagher Larijani

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  1. Hamzeh Saberi
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Correspondence to Reza Meshkani.

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Saberi, H., Mohammadtaghvaei, N., Gulkho, S. et al. The ENPP1 K121Q polymorphism is not associated with type 2 diabetes and related metabolic traits in an Iranian population. Mol Cell Biochem 350, 113–118 (2011). https://doi.org/10.1007/s11010-010-0687-z

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  • DOI: https://doi.org/10.1007/s11010-010-0687-z

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