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Interleukin-10 −1082 promoter polymorphism and gastric cancer risk in a Chinese Han population

Molecular and Cellular Biochemistry volume 347, pages 89–93 (2011)Cite this article

Abstract

Studies investigating the association between interleukin-10 (IL-10) −1082 promoter polymorphism and gastric cancer risk report conflicting results. Our recent meta-analysis suggests that the IL-10 −1082 promoter polymorphism may be associated with gastric cancer among Asians. The objective of this study was to investigate the association between IL-10 −1082 promoter polymorphism and gastric cancer risk in Chinese Han patients. We extracted the peripheral blood samples in 150 patients with gastric cancer and 150 controls. PCR-RFLP analysis was performed to detect IL-10 −1082 promoter polymorphism in these patients. Patients with gastric cancer had a significantly lower frequency of AA (OR = 0.45, 95% CI = 0.27, 0.76; P = 0.003) than controls. Patients with cardia gastric cancer had a significantly higher frequency of GG (OR = 2.17, 95% CI = 1.08, 4.38; P = 0.03) than those with noncardia gastric cancer. Patients with advanced gastric cancer had a significantly higher frequency of AA (OR = 5.21, 95% CI = 1.71, 15.87; P = 0.004) than those with early gastric cancer. When stratified by the Lauren’s classification, histological differentiation of gastric cancer, no statistically significant results were observed. This study suggests that the IL-10 −1082 promoter polymorphism may be associated with gastric cancer in Chinese Han patients, and that difference in genotype distribution may be associated with the location and stage of gastric cancer.

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Funding/support

The research of this article is supported by National Natural Science Foundation of China (No. 30901427).

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Affiliations

  1. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, 37 Guo Xue Rd, Chengdu, 610041, Sichuan Province, China

    Yong Zhou, Wen Zhuang & Xiaoting Wu

  2. Department of Clinical Nutrition, West China Hospital, Sichuan University, Chengdu, 610041, China

    Wen Hu

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  1. Yong Zhou
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  2. Wen Hu
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  3. Wen Zhuang
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  4. Xiaoting Wu
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Correspondence to Xiaoting Wu.

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Zhou, Y., Hu, W., Zhuang, W. et al. Interleukin-10 −1082 promoter polymorphism and gastric cancer risk in a Chinese Han population. Mol Cell Biochem 347, 89–93 (2011). https://doi.org/10.1007/s11010-010-0616-1

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  • DOI: https://doi.org/10.1007/s11010-010-0616-1

Keywords

  • Gastric cancer
  • Interleukin-10
  • Gene polymorphism