Abstract
To date, the calcium-regulated membrane guanylate cyclase Rod Outer Segment Guanylate Cyclase type 1 (ROS-GC1) transduction system in addition to photoreceptors is known to be expressed in three other types of neuronal cells: in the pinealocytes, mitral cells of the olfactory bulb and the gustatory epithelium of tongue. Very recent studies from our laboratory show that expression of ROS-GC1 is not restricted to the neuronal cells; the male gonads and the spermatozoa also express ROS-GC1. In this presentation, the authors review the existing information on the localization and function of guanylate cyclase with special emphasis on Ca2+-modulated membrane guanylate cyclase, ROS-GC1, in the testes. The role of ROS-GC1 and its Ca2+-sensing modulators in the processes of spermatogenesis and fertilization are discussed.
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Acknowledgments
The author (A.J.) wishes to thank Dr. Teresa Duda for the cherished support in preparing this manuscript and for her continuous encouragement and Dr. Rameshwar K. Sharma for laying the groundwork and setting up the study.
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Jankowska, A., Warchol, J.B. Ca2+-modulated membrane guanylate cyclase in the testes. Mol Cell Biochem 334, 169–179 (2010). https://doi.org/10.1007/s11010-009-0329-5
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DOI: https://doi.org/10.1007/s11010-009-0329-5