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Receptor guanylyl cyclase C (GC-C): regulation and signal transduction

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Abstract

Receptor guanylyl cyclase C (GC-C) is the target for the gastrointestinal hormones, guanylin, and uroguanylin as well as the bacterial heat-stable enterotoxins. The major site of expression of GC-C is in the gastrointestinal tract, although this receptor and its ligands play a role in ion secretion in other tissues as well. GC-C shares the domain organization seen in other members of the family of receptor guanylyl cyclases, though subtle differences highlight some of the unique features of GC-C. Gene knock outs in mice for GC-C or its ligands do not lead to embryonic lethality, but modulate responses of these mice to stable toxin peptides, dietary intake of salts, and development and differentiation of intestinal cells. It is clear that there is much to learn in future about the role of this evolutionarily conserved receptor, and its properties in intestinal and extra-intestinal tissues.

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Acknowledgements

The work in the authors’ laboratory has been supported by the Departments of Science and Technology, and Biotechnology, Government of India. NB is a Junior Research Fellow of the Council of Scientific and Industrial Research, and NA is supported by a fellowship from the Indian Institute of Science. We thank all the current and past members of the laboratory for their stimulating discussions and their outstanding enthusiasm in pursuing aspects of GC-C regulation, its ligands and signaling mechanisms.

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  1. Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, 560012, India

    Nirmalya Basu, Najla Arshad & Sandhya S. Visweswariah

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  1. Nirmalya Basu
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  2. Najla Arshad
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  3. Sandhya S. Visweswariah
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Correspondence to Sandhya S. Visweswariah.

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Basu, N., Arshad, N. & Visweswariah, S.S. Receptor guanylyl cyclase C (GC-C): regulation and signal transduction. Mol Cell Biochem 334, 67–80 (2010). https://doi.org/10.1007/s11010-009-0324-x

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