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Role of genetic polymorphism of estrogen receptor-α gene and risk of prostate cancer in north Indian population

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Abstract

Present study depicted the role of polymorphisms in estrogen receptor-α gene in association with prostate cancer in north Indian population. The study was performed on 157 cases of prostate cancer, 170 cases of BPH, and 170 healthy Indian males diagnosed with prostate cancer and benign prostatic hyperplasia (BPH) and healthy males as controls. Determination of polymorphism in the ER-α gene was done by polymerase chain reaction followed by restriction fragment length polymorphism (RFLP) analysis with PvuII and XbaI enzymes. An association was observed between PvuII polymorphism of ER-α gene and that of prostate cancer. However, there was no such association with XbaI polymorphism in ER-α gene.

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Acknowledgments

The research was supported by Indian council of medical research, New Delhi for financial assistance. The authors are grateful to Dr. Avinash Kumar Goyal, Dr. Amarjit Sharma, and Staff of respective urology departments of respective premier institutes for their cooperation and assistance for collection of samples.

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Authors and Affiliations

  1. Department of Biotechnology, Panjab University, Chandigarh, 160014, India

    Lipsy Gupta, Hitender Thakur & Ranbir C. Sobti

  2. Department of Urology, All India Institute of Medical Sciences, New Delhi, India

    Amlesh Seth

  3. Department of Urology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160014, India

    Sharwan K. Singh

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  1. Lipsy Gupta
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  2. Hitender Thakur
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  3. Ranbir C. Sobti
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Correspondence to Lipsy Gupta.

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Gupta, L., Thakur, H., Sobti, R.C. et al. Role of genetic polymorphism of estrogen receptor-α gene and risk of prostate cancer in north Indian population. Mol Cell Biochem 335, 255–261 (2010). https://doi.org/10.1007/s11010-009-0275-2

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  • DOI: https://doi.org/10.1007/s11010-009-0275-2

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