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Correlation among soluble markers and severity of disease in non-diabetic subjects with pre-mature coronary artery disease

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Abstract

Studies are lacking in literature, which demonstrate the cumulative impact of certain soluble markers in predicting the severity of CAD. Serum hsCRP, MMP-9, TIMP-1 and sRAGE levels were measured in non-diabetic 100 angiographically proven CAD patients (Group I) and 40 non-diabetic subjects with coronary risk factors and without any lesions (Group II). Increased levels of serum hsCRP, MMP-9, TIMP-1 and decreased levels of sRAGE were observed in Group I as compared to Group II. Gensini score, a measure for severity of CAD was found to be positively correlated with serum hsCRP, MMP-9, TIMP-1 and negatively with sRAGE. Multivariate analysis revealed serum MMP-9, hsCRP, sRAGE and family history as predictors of severity of CAD with a cumulative sensitivity and specificity of 92% and 82%, respectively. Cumulative impact of these soluble markers, in addition to the established markers will contribute to improve the predictive value for the assessment of disease severity.

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Acknowledgments

The authors wish to thank Indian Council of Medical Research (ICMR), New Delhi for financial assistance. Nitin Mahajan and Namita Malik were awarded Senior Research Fellowships by ICMR, New Delhi. We are also grateful to all the study subjects who participated in the present study and the laboratory staff for their technical support.

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Authors and Affiliations

  1. Department of Experimental Medicine & Biotechnology, Postgraduate Institute of Medical Education & Research (PGIMER), Research Block ‘B’, Chandigarh, 160012, India

    Nitin Mahajan, Namita Malik & Veena Dhawan

  2. Department of Cardiology, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, 160012, India

    Ajay Bahl & Yashpaul Sharma

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  1. Nitin Mahajan
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  2. Namita Malik
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Correspondence to Veena Dhawan.

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Mahajan, N., Malik, N., Bahl, A. et al. Correlation among soluble markers and severity of disease in non-diabetic subjects with pre-mature coronary artery disease. Mol Cell Biochem 330, 201–209 (2009). https://doi.org/10.1007/s11010-009-0134-1

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  • DOI: https://doi.org/10.1007/s11010-009-0134-1

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