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Hen lysozyme amyloid fibrils induce aggregation of erythrocytes and lipid vesicles


We have studied the interaction of hen egg white lysozyme (HEWL) amyloid fibrils with human erythrocytes and lipid vesicles. The fibrils caused extensive aggregation of human erythrocytes and lipid vesicles without any significant lysis. The membrane activity of HEWL fibrils suggests that the interaction of lysozyme fibrils with cellular membranes could be a contributing factor under disease conditions.

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We thank Dr. Shashi Singh, Centre for Cellular and Molecular Biology, Hyderabad, for help in recording AFM images of HEWL fibrils.

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Correspondence to Ramakrishnan Nagaraj.

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Chaudhary, N., Nagaraj, R. Hen lysozyme amyloid fibrils induce aggregation of erythrocytes and lipid vesicles. Mol Cell Biochem 328, 209–215 (2009).

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  • Lysozyme fibrils
  • Membrane interaction
  • Erythrocytes
  • Lipid vesicles