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The phosphorylation status of merlin in sporadic vestibular Schwannomas

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Abstract

The events leading to Schwannomas development are still largely unknown. Some studies have demonstrated that merlin acts as a tumor suppressor by blocking Ras-mediated signaling. In this study, we analyze the clinical and biological behaviors of seven randomly selected sporadic vestibular Schwannomas removed from the patients. We find that merlin was commonly lost in these Schwannomas, due to loss of merlin expression or phosphorylation status of merlin expression. Heightened CDKs/cyclins signal transduction concomitant with loss of p27 was well correlated with loss of functional merlin in Schwannomas. More, we show that phosphorylated merlin Schwannomas exhibited increased Ras/Rac/PAK signal transduction. That was in agreement with the severe clinical behaviors, i.e., phosphorylation status of merlin increased tumor size in sporadic vestibular Schwannomas. These results led us to suggest that phosphorylated merlin, a kind of type of mutation merlin, is involved in tumorigenesis of sporadic vestibular Schwannomas.

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Acknowledgments

This work was supported by the Natural Science Foundation of China (30672293).

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Authors and Affiliations

  1. Department of Otolaryngology – Head & Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China

    Zhaoyan Wang & Hao Wu

  2. Laboratory of Biochemistry and Molecular Biology, Tongji University, 1239 Siping Road, Shanghai, 200092, China

    Yanjun Lu, Juanjuan Tang & Haojie Wang

Authors
  1. Zhaoyan Wang
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  2. Yanjun Lu
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  3. Juanjuan Tang
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  4. Haojie Wang
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  5. Hao Wu
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Corresponding author

Correspondence to Hao Wu.

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Zhaoyan Wang and Yanjun Lu have contributed equally to this work.

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Wang, Z., Lu, Y., Tang, J. et al. The phosphorylation status of merlin in sporadic vestibular Schwannomas. Mol Cell Biochem 324, 201–206 (2009). https://doi.org/10.1007/s11010-008-0014-0

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  • DOI: https://doi.org/10.1007/s11010-008-0014-0

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