Abstract
Ribosomal S6 kinase 2 (S6K2) is one of the kinases regulated by the mammalian target of rapamycin (mTOR) signaling pathway. Although it has been identified as a kinase homologous to S6K1, evidence suggests that the two kinases have non-overlapping functions, and the biological function of S6K2 still remains unknown. In order to identify the cell cycle stage(s) during which S6K2 plays a role, we assessed changes in the catalytic activity of S6K2 throughout the cell cycle. Our data show that S6K2 is active throughout the cell cycle with higher activity in G2 and M phases. We also show that S6K1 activity peaks sharply during M phase. Our data suggest that S6K1 and S6K2 likely play yet-unknown roles in G2 and M phases.
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Abbreviations
- S6K1:
-
Ribosomal S6 kinase 1
- S6K2:
-
Ribosomal S6 kinase 2
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Acknowledgments
This work was supported by MBRS SCORE grant from National Institute of Health (grant no. 1 S06 GM63119-01 and 2 S06 GM063119-05) and HHMI (grant no. 52002663).
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Boyer, D., Quintanilla, R. & Lee-Fruman, K.K. Regulation of catalytic activity of S6 kinase 2 during cell cycle. Mol Cell Biochem 307, 59–64 (2008). https://doi.org/10.1007/s11010-007-9584-5
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DOI: https://doi.org/10.1007/s11010-007-9584-5