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Molecular and Cellular Biochemistry

, Volume 303, Issue 1–2, pp 39–44 | Cite as

Antioxidant effect of the marine algae Chlorella vulgaris against naphthalene-induced oxidative stress in the albino rats

  • K. VijayavelEmail author
  • C. Anbuselvam
  • M. P. Balasubramanian
Article

Abstract

Alcoholic extract of the marine algae Chlorella vulgaris was examined for its free radical scavenging effect with reference to naphthalene-induced lipid peroxidation in serum, liver, and kidney of rats. Initially, upon naphthalene intoxication (435 mg/kg body weight, intraperitoneally), the lipid peroxidation activity increased significantly (P < 0.001), and in contrast, the enzymic antioxidants (superoxide dismutase, catalase, glutathione peroxidase) and non-enzymic antioxidants (glutathione, ascorbic acid, and α-tocopherol) levels decreased remarkably. When the naphthalene stressed rats were treated with Chlorella vulgaris extract (70 mg/kg body weight, orally), the lipid peroxidation activity reduced significantly (P < 0.001) and the activities of both the enzymic and non-enzymic antioxidants increased reaching near control values. The minimum concentration (70 mg/l) of the extract that exhibited maximum (85%) free radical scavenging activity was chosen for the experimental study. The present results suggest that Chlorella vulgaris extract exerts its chemo-preventive effect by modulating the antioxidants status and lipid peroxidation during naphthalene intoxication.

Keywords

Chlorellavulgaris Free radical scavengers Naphthalene Lipid peroxidation 

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • K. Vijayavel
    • 1
    • 2
    Email author
  • C. Anbuselvam
    • 1
  • M. P. Balasubramanian
    • 1
  1. 1.Department of Pharmacology and Environmental Toxicology, Dr. ALM Post Graduate Institute of Basic Medical SciencesUniversity of MadrasChennaiIndia
  2. 2.Water Resources Research CenterUniversity of Hawaii at ManoaHonoluluUSA

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