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Effect of Ascorbic Acid Supplementation on Certain Oxidative Stress Parameters in the Post Reperfusion Patients of Myocardial Infarction

Molecular and Cellular Biochemistry volume 290, pages 153–158 (2006)Cite this article

Abstract

Reperfusion injury causes oxidative stress thereby resulting in an imbalance between oxidant-antioxidant systems. In the present communication, the effect of ascorbic acid supplementation has been studied on certain oxidant and antioxidant parameters in the blood of the patients with myocardial infarction before and after thrombolysis. In patients after thrombolysis, the activity of antioxidant enzyme, superoxide dismutase, in the blood was found to be significantly reduced where as the activity of the oxidant enzyme, xanthine oxidase, was found to be significantly increased. Malondialdehyde levels, the index of free radical mediated damage, was also found to be significantly elevated in thrombolyzed patients compared to the patients before thrombolysis. Supplementation of vitamin C to the post reperfusion patients restored these parameters back to normal or near normal levels.

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Affiliations

  1. Department of Biochemistry, Lucknow University, Lucknow, 226007, India

    Pushpa Bhakuni & M. K. Misra

  2. Department of Medicine, ICU, King George's Medical University, Lucknow, India

    M. Chandra

Authors
  1. Pushpa Bhakuni
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  2. M. Chandra
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  3. M. K. Misra
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Correspondence to M. K. Misra.

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Bhakuni, P., Chandra, M. & Misra, M.K. Effect of Ascorbic Acid Supplementation on Certain Oxidative Stress Parameters in the Post Reperfusion Patients of Myocardial Infarction. Mol Cell Biochem 290, 153–158 (2006). https://doi.org/10.1007/s11010-006-9182-y

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  • DOI: https://doi.org/10.1007/s11010-006-9182-y

Keywords

  • myocardial infarction
  • free radical scavengers
  • ascorbic acid
  • thiols
  • oxidative stress