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Ameliorating role of caffeic acid phenethyl ester (CAPE) against isoniazid-induced oxidative damage in red blood cells

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Abstract

Isoniazid (INH) still remains a first-line drug both for treatment and prophylaxis of tuberculosis, but various organs toxicity frequently develops in patients receiving this drug. We aimed to investigate possible toxic effects of INH on rat red blood cells (RBCs), and to elucidate whether Caffeic acid phenethyl ester (CAPE) prevents a possible toxic effect of INH. Experimental groups were designed as follows: control group, INH group, INH + CAPE group. Compared with the control, the INH caused a significant increase in superoxide dismutase (SOD) activity and malondialdehyde (MDA) levels, and a decrease in glutathione peroxidase (GSH-Px) and catalase (CAT), which are recently used to monitor the development and extent of damage due to oxidative stresses. CAPE administration to INH group ameliorated above changes due to INH.

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Authors and Affiliations

  1. Faculty of Medicine, Department of Pharmacology, Suleyman Demirel University, Isparta, Turkey

    Osman Gokalp MD, Ekrem Cicek & Mehmet Kaya Ozer

  2. Faculty of Medicine, Department of Medical Biology and Genetics, Suleyman Demirel University, Isparta, Turkey

    Efkan Uz, H. Ramazan Yilmaz, Ayse Altunbas & Nurten Ozcelik

  3. Faculty of Medicine, Department of Pharmacology, Suleyman Demirel University, Morfoloji Binasi, 32260, Cunur-Isparta, Turkey

    Osman Gokalp MD

Authors
  1. Osman Gokalp MD
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  2. Efkan Uz
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  3. Ekrem Cicek
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  4. H. Ramazan Yilmaz
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  5. Mehmet Kaya Ozer
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  6. Ayse Altunbas
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  7. Nurten Ozcelik
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Correspondence to Osman Gokalp MD.

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Gokalp, O., Uz, E., Cicek, E. et al. Ameliorating role of caffeic acid phenethyl ester (CAPE) against isoniazid-induced oxidative damage in red blood cells. Mol Cell Biochem 290, 55–59 (2006). https://doi.org/10.1007/s11010-006-9157-z

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  • DOI: https://doi.org/10.1007/s11010-006-9157-z

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