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Decreased bodyweight without rebound and regulated lipoprotein metabolism by gymnemate in genetic multifactor syndrome animal

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Abstract

Objective: The aim of this work was to find obesity control method without rebound. In our previous studies, gymnemate extracted from Gymnema sylvestre, inhibited oleic acid absorption. The Otsuka Long-Evans Tokushima Fatty (OLETF) rat, a genetic multifactor syndrome model, exhibits progressive overweight, hyperlipidemia and hyperglycemia. The effect of gymnemate on obesity in OLETF was investigated. Methods: Three groups were divided (n = 4–8): (1) OLETF-gymnemate, gymnema water extract (containing gymnemate) diet (62.5 g/kg) and water (2.5 g/kg) were supplied 2 weeks from 26–28 weeks, following it general diet and water were fed 3 weeks to observe if it rebound, (2) OLETF-control and (3) the counterpart Long-Evans Tokushima Otsuka rats as normal-control. Results: With gymnemate treatment, the food and water intake were decreased about 1/3 and 2/3, along with body weight reduced 57.2± 6.4 and 75.5± 6.3 g during 1 and 2 weeks respectively. In the end of experiment (3 weeks after gymnemate withdrawal), the body weight was decreased to no significant difference with normal-control. The total cholesterol was decreased about 1/3, moreover LDL+VLDL (low-density and very-low-density lipoprotein) cholesterol decreased about 1/2. The proportion of HDL (high-density lipoprotein) cholesterol to the total cholesterol was increased. The serum triglyceride was decreased to the 1/4 of OLETF control. The level of serum cholesterol and triglyceride was no significant difference in gymnemate group with normal group. Conclusion: Supplementation with gymnemate promotled weight loss by its ability to reduce hyperlipidemia, which was no withdrawal rebound: an important discovery. Supplementation with gymnemate is a novel therapeutic tool for weight management, especially in multifactor syndrome.

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Authors and Affiliations

  1. Department of Pathophysiological and Therapeutic Science, Division of Medical Biochemistry, Faculty of Medicine, Tottori University, Yonago, 683-8503, Japan

    Hong Luo & Kazuo Yamada

  2. Division of Laboratory Animal Science, Research Center for Bioscience and Technology, Tottori University, Tottori, Japan

    Hong Luo, Akiko Kashiwagi & Toshiyuki Shibahara

  3. International Department, The Japan Society for the Promotion of Science (JSPS), Tokyo, Japan

    Hong Luo

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  1. Hong Luo
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  2. Akiko Kashiwagi
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  4. Kazuo Yamada
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Correspondence to Hong Luo.

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Luo, H., Kashiwagi, A., Shibahara, T. et al. Decreased bodyweight without rebound and regulated lipoprotein metabolism by gymnemate in genetic multifactor syndrome animal. Mol Cell Biochem 299, 93–98 (2007). https://doi.org/10.1007/s11010-005-9049-7

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