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New Functions of a Well-Known Protein: Prothymosin α Is Involved in Protecting Cells from Apoptosis and Oxidative Stress

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Abstract

Recent studies have revealed two new functions of prothymosin α (ProTα), a well-known protein and a subject of intense research. In addition to acting as an immunomodulator and stimulating cell proliferation, ProTα is involved in protecting the cell from apoptosis and regulating the expression of oxidative stress defense genes. The review considers the methods and approaches used to demonstrate the two new functions of ProTα.

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Authors and Affiliations

  1. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, 119992, Russia

    A. G. Evstafieva, R. N. Karapetian, Yu. P. Rubtsov, G. S. Filonov, I. S. Abaeva, T. V. Fateeva, S. V. Melnikov, N. V. Chichkova & A. B. Vartapetian

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  1. A. G. Evstafieva
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  2. R. N. Karapetian
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  3. Yu. P. Rubtsov
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  4. G. S. Filonov
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  5. I. S. Abaeva
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  6. T. V. Fateeva
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  8. N. V. Chichkova
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  9. A. B. Vartapetian
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__________

Translated from Molekulyarnaya Biologiya, Vol. 39, No. 5, 2005, pp. 729–745.

Original Russian Text Copyright © 2005 by Evstafieva, Karapetian, Rubtsov, Filonov, Abaeva, Fateeva, Melnikov, Chichkova, Vartapetian.

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Evstafieva, A.G., Karapetian, R.N., Rubtsov, Y.P. et al. New Functions of a Well-Known Protein: Prothymosin α Is Involved in Protecting Cells from Apoptosis and Oxidative Stress. Mol Biol 39, 631–645 (2005). https://doi.org/10.1007/s11008-005-0079-8

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