Abstract
Purpose
The objective of this review is to examine factors, during the perinatal period, that serve to protect women and infants from poor mental or physical outcomes most commonly associated with maternal adverse childhood experiences (ACEs).
Methods
The electronic databases of PubMed, Ovid MEDLINE, CINAHL and Web of Science were searched. The searches were conducted using the following mesh terms and keywords: (‘adverse childhood experiences’ or ‘ACEs’) and (‘protective factor’ or ‘social support’ or ‘buffer’ or ‘resilience’) and (‘pregnan*’ or ‘prenatal’ or ‘postpartum’ or ‘maternal’ or ‘antenatal’). Studies that examined the association of maternal ACEs and protective factors during the perinatal period were included. A total of 317d articles were screened and 19 are included in this review. The quality of the articles was evaluated with the Newcastle–Ottawa-Scale (NOS).
Results and Conclusion
This review indicates a positive association between maternal ACEs and protective perinatal factors including social support, resiliency and positive childhood experiences.
Significance
Demonstrated associations between maternal ACEs and poor mental and physical outcomes for mother and baby make it critical to understand existing research regarding factors that may be protective against the effects of ACEs during the perinatal period. Despite a growing body of research showing the negative effects of maternal ACEs on health, less understood are protective factors which may counteract or lessen the effects of ACEs. An understanding of protective factors is necessary to inform how clinicians assess and provide care for ACE exposed perinatal women.
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Data Availability
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Code Availability
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References
Accortt, E. E., Cheadle, A. C. D., & Dunkel Schetter, C. (2015). Prenatal depression and adverse birth outcomes: An updated systematic review. Maternal and Child Health Journal, 19(6), 1306–1337. https://doi.org/10.1007/s10995-014-1637-2
Ångerud, K., Annerbäck, E.-M., Tydén, T., Boddeti, S., & Kristiansson, P. (2018). Adverse childhood experiences and depressive symptomatology among pregnant women. Acta Obstetricia Et Gynecologica Scandinavica, 97(6), 701–708. https://doi.org/10.1111/aogs.13327
Appleton, A. A., Kiley, K., Holdsworth, E. A., & Schell, L. M. (2019). Social support during pregnancy modifies the association between maternal adverse childhood experiences and infant birth size. Maternal and Child Health Journal, 23(3), 408–415. https://doi.org/10.1007/s10995-018-02706-z
Avalos, L. A., Flanagan, T., & Li, D.-K. (2019). Preventing perinatal depression to improve maternal and child health—a health care imperative. JAMA Pediatrics, 173(4), 313. https://doi.org/10.1001/jamapediatrics.2018.5491
Beutel, M. E., Tibubos, A. N., Klein, E. M., Schmutzer, G., Reiner, I., Kocalevent, R.-D., & Brähler, E. (2017). Childhood adversities and distress—the role of resilience in a representative sample. PLOS ONE, 12(3), e0173826. https://doi.org/10.1371/journal.pone.0173826
Blalock, J. A., Nayak, N., Wetter, D. W., Schreindorfer, L., Minnix, J. A., Canul, J., & Cinciripini, P. M. (2011). The relationship of childhood trauma to nicotine dependence in pregnant smokers. Psychology of Addictive Behaviors, 25(4), 652–663. https://doi.org/10.1037/a0025529
Bödeker, K., Fuchs, A., Führer, D., Kluczniok, D., Dittrich, K., Reichl, C., Reck, C., Kaess, M., Hindi Attar, C., Möhler, E., Neukel, C., Bierbaum, A.-L., Zietlow, A.-L., Jaite, C., Lehmkuhl, U., Winter, S. M., Herpertz, S., Brunner, R., Bermpohl, F., & Resch, F. (2019). Impact of maternal early life maltreatment and maternal history of depression on child psychopathology: Mediating role of maternal sensitivity? Child Psychiatry & Human Development, 50(2), 278–290. https://doi.org/10.1007/s10578-018-0839-z
Braveman, P., Heck, K., Egerter, S., Rinki, C., Marchi, K., & Curtis, M. (2018). Economic hardship in childhood: A neglected issue in ACE studies? Maternal and Child Health Journal, 22(3), 308–317. https://doi.org/10.1007/s10995-017-2368-y
Campbell, J. A., Walker, R. J., & Egede, L. E. (2016). Associations between adverse childhood experiences, high-risk behaviors, and morbidity in adulthood. American Journal of Preventive Medicine, 50(3), 344–352. https://doi.org/10.1016/j.amepre.2015.07.022
Christiaens, I., Hegadoren, K., & Olson, D. M. (2015). Adverse childhood experiences are associated with spontaneous preterm birth: A case–control study. BMC Medicine, 13(1), 124. https://doi.org/10.1186/s12916-015-0353-0
Chung, E. K., Mathew, L., Elo, I. T., Coyne, J. C., & Culhane, J. F. (2008). Depressive symptoms in disadvantaged women receiving prenatal care: The influence of adverse and positive childhood experiences. Ambulatory Pediatrics: The Official Journal of the Ambulatory Pediatric Association, 8(2), 109–116. https://doi.org/10.1016/j.ambp.2007.12.003
Chung, E. K., Nurmohamed, L., Mathew, L., Elo, I. T., Coyne, J. C., & Culhane, J. F. (2010). Risky health behaviors among mothers-to-be: The impact of adverse childhood experiences. Academic Pediatrics, 10(4), 245–251. https://doi.org/10.1016/j.acap.2010.04.003
Cohen, S., & Hoberman, H. M. (2019). Interpersonal support evaluation list. APA PsycTests. https://doi.org/10.1037/t06207-000
Connor, K. M., & Davidson, J. R. T. (2003). Development of a new resilience scale: The Connor-Davidson resilience scale (CD-RISC). Depression and Anxiety, 18(2), 76–82. https://doi.org/10.1002/da.10113
East, C. E., Biro, M. A., Fredericks, S., & Lau, R. (2019). Support during pregnancy for womenat increased risk of low birthweight babies. The Cochrane Database of Systematic Reviews, 4, CD000198. https://doi.org/10.1002/14651858.CD000198.pub3
Fatima, M., Srivastav, S., & Mondal, A. C. (2017). Prenatal stress and depression associated neuronal development in neonates. International Journal of Developmental Neuroscience, 60(1), 1–7. https://doi.org/10.1016/j.ijdevneu.2017.04.001
Felitti, V. J., Anda, R. F., Nordenberg, D., Williamson, D. F., Spitz, A. M., Edwards, V., Koss, M. P., & Marks, J. S. (1998). Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. American Journal of Preventive Medicine, 14(4), 245–258. https://doi.org/10.1016/S0749-3797(98)00017-8
Institute, Fetzer. (1999). Mulidimensional measurement of religiousness/spirituality for use in health research. Fetzer Institute.
Field, T. (2017). Prenatal depression risk factors, developmental effects and interventions: A review. Journal of Pregnancy and Child Health, 4(1), 301. https://doi.org/10.4172/2376-127X.1000301
Frankenberger, D. J., Clements-Nolle, K., & Yang, W. (2015). The association between adverse childhood experiences and alcohol use during pregnancy in a representative sample of adult women. Women’s Health Issues, 25(6), 688–695. https://doi.org/10.1016/j.whi.2015.06.007
Gavin, A. R., Hill, K. G., Hawkins, J. D., & Maas, C. (2011). The role of maternal early-life and later-life risk factors on offspring low birth weight: Findings from a three-generational study. Journal of Adolescent Health, 49(2), 166–171. https://doi.org/10.1016/j.jadohealth.2010.11.246
Handelzalts, J. E., Stringer, M. K., Menke, R. A., & Muzik, M. (2020). The association of religion and spirituality with postpartum mental health in women with childhood maltreatment histories. Journal of Child and Family Studies, 29(2), 502–513. https://doi.org/10.1007/s10826-019-01595-2
Hantsoo, L., Jašarević, E., Criniti, S., McGeehan, B., Tanes, C., Sammel, M. D., Elovitz, M. A., Compher, C., Wu, G., & Epperson, C. N. (2019). Childhood adversity impact on gut microbiota and inflammatory response to stress during pregnancy. Brain, Behavior, and Immunity, 75, 240–250. https://doi.org/10.1016/j.bbi.2018.11.005
Helgeson, V. S. (2003). Social support and quality of life. Quality of Life Research, 12(1suppl), 25–31. https://doi.org/10.1023/A:1023509117524
Hetherington, E., Doktorchik, C., Premji, S. S., McDonald, S. W., Tough, S. C., & Sauve, R. S. (2015). Preterm birth and social support during pregnancy: A systematic review and meta-analysis: Preterm birth and social support meta-analysis. Paediatric and Perinatal Epidemiology, 29(6), 523–535. https://doi.org/10.1111/ppe.12225
Howell, K. H., Miller-Graff, L. E., Schaefer, L. M., & Scrafford, K. E. (2017). Relational resilience as a potential mediator between adverse childhood experiences and prenatal depression. Journal of Health Psychology. https://doi.org/10.1177/1359105317723450
Ilter Bahadur, E., Asena, M., Yavuz, Y., Karabulut, E., & Ozmert, E. N. (2021). The role of adverse childhood experience and social support type in postpartum depression in Turkey. Journal of Obstetrics and Gynaecology Research, 47(12), 4289–4297. https://doi.org/10.1111/jog.15049
Jaffee, S. R., Takizawa, R., & Arseneault, L. (2017). Buffering effects of safe, supportive, and nurturing relationships among women with childhood histories of maltreatment. Psychological Medicine, 47(15), 2628–2639. https://doi.org/10.1017/S0033291717001027
Kalmakis, K. A., & Chandler, G. E. (2015). Health consequences of adverse childhood experiences: A systematic review. Journal of the American Association of Nurse Practitioners, 27(8), 457–465. https://doi.org/10.1002/2327-6924.12215
Leeners, B., Rath, W., Block, E., Görres, G., & Tschudin, S. (2014). Risk factors for unfavorable pregnancy outcome in women with adverse childhood experiences. Journal of Perinatal Medicine. https://doi.org/10.1515/jpm-2013-0003
Letourneau, N., Dewey, D., Kaplan, B. J., Ntanda, H., Novick, J., Thomas, J. C., Deane, A. J., Leung, B., Pon, K., Giesbrecht, G. F., the APrON Study Team. (2019). Intergenerational transmission of adverse childhood experiences via maternal depression and anxiety and moderation by child sex. Journal of Developmental Origins of Health and Disease, 10(1), 88–99. https://doi.org/10.1017/S2040174418000648
Lydsdottir, L. B., Howard, L. M., Olafsdottir, H., Einarsson, H., Steingrimsdottir, T., & Sigurdsson, J. F. (2019). Adverse life experiences and common mental health problems in pregnancy: A causal pathway analysis. Archives of Womens Mental Health, 22(1), 75–83. https://doi.org/10.1007/s00737-018-0881-7
Masten, A. S. (2014). Invited commentary: Resilience and positive youth development frameworks in developmental science. Journal of Youth and Adolescence, 43(6), 1018–1024. https://doi.org/10.1007/s10964-014-0118-7
McDonnell, C. G., & Valentino, K. (2016). Intergenerational effects of childhood trauma: Evaluating pathways among maternal ACEs, perinatal depressive symptoms, and infant outcomes. Child Maltreatment, 21(4), 317–326. https://doi.org/10.1177/1077559516659556
Merrick, J. S., Narayan, A. J., Atzl, V. M., Harris, W. W., & Lieberman, A. F. (2020). Type versus timing of adverse and benevolent childhood experiences for pregnant women’s psychological and reproductive health. Children and Youth Services Review, 114, 105056. https://doi.org/10.1016/j.childyouth.2020.105056
Merrick, M. T., Ford, D. C., Ports, K. A., & Guinn, A. S. (2018). Prevalence of adverse childhood experiences from the 2011–2014 Behavioral risk factor surveillance system in 23 states. JAMA Pediatrics, 172(11), 1038. https://doi.org/10.1001/jamapediatrics.2018.2537
Moog, N. K., Heim, C. M., Entringer, S., Kathmann, N., Wadhwa, P. D., & Buss, C. (2017). Childhood maltreatment is associated with increased risk of subclinical hypothyroidism in pregnancy. Psychoneuroendocrinology, 84, 190–196. https://doi.org/10.1016/j.psyneuen.2017.07.482
Muzik, M., Umarji, R., Sexton, M. B., & Davis, M. T. (2017). Family social support modifies the relationships between childhood maltreatment severity, economic adversity and postpartum depressive symptoms. Maternal and Child Health Journal, 21(5), 1018–1025. https://doi.org/10.1007/s10995-016-2197-4
Narayan, A. J., Ghosh, I., Rivera, L. M., & Lieberman, A. F. (2015). The benevolent childhood experiences scale. University of California.
Narayan, A. J., Rivera, L. M., Bernstein, R. E., Harris, W. W., & Lieberman, A. F. (2018). Positive childhood experiences predict less psychopathology and stress in pregnant women with childhood adversity: A pilot study of the benevolent childhood experiences (BCEs) scale. Child Abuse & Neglect, 78, 19–30. https://doi.org/10.1016/j.chiabu.2017.09.022
Nidey, N., Bowers, K., Ammerman, R. T., Shah, A. N., Phelan, K. J., Clark, M. J., Van Ginkel, J. B., & Folger, A. T. (2020). Combinations of adverse childhood events and risk of postpartum depression among mothers enrolled in a home visiting program. Annals of Epidemiology. https://doi.org/10.1016/j.annepidem.2020.09.015
Nowak, A. L., Braungart-Rieker, J. M., & Kuo, P. X. (2022). Social support moderates the relation between childhood trauma and prenatal depressive symptoms in adolescent mothers. Journal of Reproductive and Infant Psychology, 40(6), 644–658. https://doi.org/10.1080/02646838.2021.1938980
Nylen, K. J., O’Hara, M. W., & Engeldinger, J. (2013). Perceived social support interacts with prenatal depression to predict birth outcomes. Journal of Behavioral Medicine, 36(4), 427–440. https://doi.org/10.1007/s10865-012-9436-y
Osofsky, J. D., Osofsky, H. J., Frazer, A. L., Fields-Olivieri, M. A., Many, M., Selby, M., Holman, S., & Conrad, E. (2021). The importance of adverse childhood experiences during the perinatal period. American Psychologist, 76(2), 350–363. https://doi.org/10.1037/amp0000770
Pascoe, J. M., & French, J. (1990). The reliability and validity of the maternal social support index for primiparous mothers: A brief report. Family Medicine, 22(3), 228–230.
Pear, V. A., Petito, L. C., & Abrams, B. (2017). The role of maternal adverse childhood experiences and race in intergenerational high-risk smoking behaviors. Nicotine & Tobacco Research, 19(5), 623–630. https://doi.org/10.1093/ntr/ntw295
Poole, J. C., Dobson, K. S., & Pusch, D. (2017). Childhood adversity and adult depression: The protective role of psychological resilience. Child Abuse & Neglect, 64, 89–100. https://doi.org/10.1016/j.chiabu.2016.12.012
Racine, N., Madigan, S., Plamondon, A., Hetherington, E., McDonald, S., & Tough, S. (2018). Maternal adverse childhood experiences and antepartum risks: The moderating role of social support. Archives of Womens Mental Health, 21(6), 663–670. https://doi.org/10.1007/s00737-018-0826-1
Racine, N., Zumwalt, K., McDonald, S., Tough, S., & Madigan, S. (2019). Perinatal depression: The role of maternal adverse childhood experiences and social support. Journal of Affective Disorders. https://doi.org/10.1016/j.jad.2019.11.030
Rini, C., Schetter, C. D., Hobel, C. J., Glynn, L. M., & Sandman, C. A. (2006). Effective social support: Antecedents and consequences of partner support during pregnancy. Personal Relationships, 13(2), 207–229. https://doi.org/10.1111/j.1475-6811.2006.00114.x
Schickedanz, A., Halfon, N., Sastry, N., & Chung, P. J. (2018). Parents’ adverse childhood experiences and their children’s behavioral health problems. Pediatrics, 142(2), e20180023. https://doi.org/10.1542/peds.2018-0023
Seng, J. S., Low, L. K., Sperlich, M., Ronis, D. L., & Liberzon, I. (2009). Prevalence, trauma history, and risk for posttraumatic stress disorder among nulliparous women in maternity care. Obstetrics & Gynecology, 114(4), 839–847. https://doi.org/10.1097/AOG.0b013e3181b8f8a2
Seng, J. S., Sperlich, M., & Low, L. K. (2008). Mental health, demographic, and risk behavior profiles of pregnant survivors of childhood and adult abuse. Journal of Midwifery & Women’s Health, 53(6), 511–521. https://doi.org/10.1016/j.jmwh.2008.04.013
Sexton, M. B., Hamilton, L., McGinnis, E. W., Rosenblum, K. L., & Muzik, M. (2015). The roles of resilience and childhood trauma history: Main and moderating effects on postpartum maternal mental health and functioning. Journal of Affective Disorders, 174, 562–568. https://doi.org/10.1016/j.jad.2014.12.036
Smilkstein, G. (1978). The family APGAR: A proposal for a family function test and its use by physicians. The Journal of Family Practice, 6(8), 1231–1239.
Smith, M. V., Gotman, N., & Yonkers, K. A. (2016). Early childhood adversity and pregnancy outcomes. Maternal and Child Health Journal, 20(4), 790–798. https://doi.org/10.1007/s10995-015-1909-5
Southwick, S. M., Bonanno, G. A., Masten, A. S., Panter-Brick, C., & Yehuda, R. (2014). Resilience definitions, theory, and challenges: Interdisciplinary perspectives. European Journal of Psychotraumatology, 5(1), 25338. https://doi.org/10.3402/ejpt.v5.25338
Stewart, C. D., & Stewart, A. L. (1991). The Medical outcoms survey social support survey. Social Science & Medicine, 32, 705–714.
Thomas, J. C., Letourneau, N., Campbell, T. S., & Giesbrecht, G. F. (2018). Social buffering of the maternal and infant HPA axes: Mediation and moderation in the intergenerational transmission of adverse childhood experiences. Development and Psychopathology, 30(3), 921–939. https://doi.org/10.1017/S0954579418000512
Ungar, M., & Liebenberg, L. (2011). Assessing resilience across cultures using mixed methods: Construction of the child and youth resilience measure. Journal of Mixed Methods Research, 5(2), 126–149. https://doi.org/10.1177/1558689811400607
Wajid, A., van Zanten, S. V., Mughal, M. K., Biringer, A., Austin, M.-P., Vermeyden, L., & Kingston, D. (2019). Adversity in childhood and depression in pregnancy. Archives of Women’s Mental Health. https://doi.org/10.1007/s00737-019-00966-4
Walsh, D., McCartney, G., Smith, M., & Armour, G. (2019). Relationship between childhood socioeconomic position and adverse childhood experiences (ACEs): A systematic review. Journal of Epidemiology and Community Health, 73(12), 1087–1093. https://doi.org/10.1136/jech-2019-212738
Wells, G. A., Shea, B., O’Connell, D., Peterson, J., Welch, V., Losos, M., & Tugwell, P. (2000). The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses.
Wingo, A. P., Ressler, K. J., & Bradley, B. (2014). Resilience characteristics mitigate tendency for harmful alcohol and illicit drug use in adults with a history of childhood abuse: A cross-sectional study of 2024 inner-city men and women. Journal of Psychiatric Research, 51, 93–99. https://doi.org/10.1016/j.jpsychires.2014.01.007
Wright, M., Masten, A. S., & Narayan, A. J. (2013). Resilience processes in development: Four waves of research on positive adaptation in the context of adversity. Handbook of resiience in children (pp. 15–37). Springer.
Young-Wolff, K. C., Alabaster, A., McCaw, B., Stoller, N., Watson, C., Sterling, S., Ridout, K. K., & Flanagan, T. (2019). Adverse childhood experiences and mental and behavioral health conditions during pregnancy: The role of resilience. Journal of Women’s Health, 28(4), 452–461. https://doi.org/10.1089/jwh.2018.7108
Youssef, N. A., Belew, D., Hao, G., Wang, X., Treiber, F. A., Stefanek, M., Yassa, M., Boswell, E., McCall, W. V., & Su, S. (2017). Racial/ethnic differences in the association of childhood adversities with depression and the role of resilience. Journal of Affective Disorders, 208, 577–581. https://doi.org/10.1016/j.jad.2016.10.024
Zhong, Q.-Y., Wells, A., Rondon, M. B., Williams, M. A., Barrios, Y. V., Sanchez, S. E., & Gelaye, B. (2016). Childhood abuse and suicidal ideation in a cohort of pregnant Peruvian women. American Journal of Obstetrics and Gynecology, 215(4), 501.e1-501.e8. https://doi.org/10.1016/j.ajog.2016.04.052
Zimet, G., Dahlem, N., Zimet, S., & Farley, G. (1988). The multidimensional scale of perceived social support. Journal of Personality Assessment, 52(1), 30–41.
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Borg, L.E., Alhusen, J.L. A Review of Factors that Serve to Protect Pregnant and Post-partum Women from Negative Outcomes Associated with Adverse Childhood Experiences. Matern Child Health J 27, 1503–1517 (2023). https://doi.org/10.1007/s10995-023-03689-2
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DOI: https://doi.org/10.1007/s10995-023-03689-2