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Similarities in Maternal Weight and Birth Weight Across Pregnancies and Across Sisters

  • Ellen Luecke
  • Alison K. Cohen
  • Miranda Brillante
  • David H. Rehkopf
  • Jeremy Coyle
  • C. Emily Hendrick
  • Barbara AbramsEmail author
Article

Abstract

Objectives The current study examined how prepregnancy body mass index (BMI), gestational weight gain, and birth weight cluster between births within women and between women who are sisters. Methods Using data from the National Longitudinal Survey of Youth 1979 cohort, we utilized nested, multivariable hierarchical linear models to examine the correlation of these three outcomes between births (n = 6006) to women (n = 3605) and sisters (n = 3170) so that we can quantify the clustering by sibship and by woman for these three pregnancy-related outcomes. Results After controlling for confounding covariates, prepregnancy BMI (intraclass correlation (ICC) 0.24, 95% CI 0.16, 0.32), gestational weight gain (ICC 0.23, 95% CI 0.16, 0.31), and infant’s birthweight (ICC 0.07, 95% CI 0.003, 0.13) were correlated between sisters. Additionally, all three outcomes were significantly correlated between births for each sister, suggesting that prepregnancy BMI (ICC 0.82, 95% CI 0.81, 0.83), gestational weight gain (ICC 0.45, 95% CI 0.42, 0.49), and birth weight (ICC 0.31, 95% CI 0.28, 0.35) track between pregnancies in the same woman. Conclusions for Practice The observed clustering both within women and between sisters suggests that shared genetic and environmental factors among sisters play a role in pregnancy outcomes above and beyond that of women’s own genetic and environmental factors. Findings suggest that asking a woman about her sisters’ pregnancy outcomes could provide insight into the possible outcomes for her current pregnancy. Future research should test if collecting such a family history and providing tailored clinical recommendations accordingly would be useful.

Keywords

Birth weight Body mass index Gestational weight gain Pregnancy Women 

Notes

Acknowledgements

This research was supported by the National Institutes of Health from the National Institute of Minority Health and Health Disparities at the National Institutes of Health (Grant 5R01MD6104-2) and under a Ruth L. Kirschstein National Research Service Award (T32HD049302) from the National Institute of Child Health and Human Development to Hendrick. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health nor the Bureau of Labor Statistics.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

References

  1. Alexander, G. R., Himes, J. H., Kaufman, R. B., Mor, J., & Kogan, M. (1996). A United States national reference for fetal growth. Obstetrics & Gynecology, 87(2), 163–168.  https://doi.org/10.1016/0029-7844(95)00386-X.CrossRefGoogle Scholar
  2. Andersson, E. S., Silventoinen, K., Tynelius, P., Nohr, E. A., Sørensen, T. I. A., & Rasmussen, F. (2015). Heritability of gestational weight gain—A Swedish register-based twin study. Twin Research and Human Genetics, 18(4), 410–418.  https://doi.org/10.1017/thg.2015.38.CrossRefPubMedGoogle Scholar
  3. Astone, N. M., Misra, D., & Lynch, C. (2007). The effect of maternal socio-economic status throughout the lifespan on infant birthweight. Paediatric and Perinatal Epidemiology, 21(4), 310–318.  https://doi.org/10.1111/j.1365-3016.2007.00821.x.CrossRefPubMedGoogle Scholar
  4. Beaty, T.H., Skjaerven, R., Breazeale, D.R., & Liang, K.Y. (1997). Analyzing sibship correlations in birth weight using large sibships from Norway. Genetic Epidemiology, 14(4), 423–433.  https://doi.org/10.1002/(SICI)1098-2272(1997)14:4%3C423::AID-GEPI7%3E3.0.CO;2-3 CrossRefPubMedGoogle Scholar
  5. Beaty, T. H., Yang, P., Muñoz, A., & Khoury, M. J. (1988). Effect of maternal and infant covariates on sibship correlation in birth weight. Genetic Epidemiology, 5(4), 241–253.  https://doi.org/10.1002/gepi.1370050406.CrossRefPubMedGoogle Scholar
  6. Bitler, M. P., & Currie, J. (2005). Does WIC work? The effects of WIC on pregnancy and birth outcomes. Journal of Policy Analysis and Management, 24(1), 73–91.  https://doi.org/10.1002/pam.20070.CrossRefPubMedGoogle Scholar
  7. Brown, H. W., & Roberts, J. (2012). Exploring the factors contributing to sibling correlations in BMI: A study using the Panel Study of Income Dynamics. Obesity, 20(5), 978–984.  https://doi.org/10.1038/oby.2011.351.CrossRefPubMedGoogle Scholar
  8. Bussières, E. L., Tarabulsy, G. M., Pearson, J., Tessier, R., Forest, J. C., & Giguère, Y. (2015). Maternal prenatal stress and infant birth weight and gestational age: A meta-analysis of prospective studies. Developmental Review, 36, 179–199.CrossRefGoogle Scholar
  9. Chin, J. R., Krause, K. M., Ostbye, T., Chowdhury, N., Lovelady, C. A., & Swamy, G. K. (2010). Gestational weight gain in consecutive pregnancies. American Journal of Obstetrics and Gynecology, 203(3), 279.e1–279.e6.  https://doi.org/10.1016/j.ajog.2010.06.038.CrossRefGoogle Scholar
  10. CHRR. (2008). NLSY79 User’s Guide. Columbus: Center for Human Resource Research, Ohio State University.Google Scholar
  11. Clausson, B., Lichtenstein, P., & Cnattingius, S. (2000). Genetic influence on birthweight and gestational length determined by studies in offspring of twins. BJOG, 107(3), 375–381.CrossRefPubMedGoogle Scholar
  12. Cohen, A. K., Kazi, C., Headen, I., Rehkopf, D. H., Hendrick, C. E., Patil, D., & Abrams, B. (2016). Educational attainment and gestational weight gain among U.S. mothers. Women’s Health Issues, 26(4), 460–467.  https://doi.org/10.1016/j.whi.2016.05.009.CrossRefPubMedPubMedCentralGoogle Scholar
  13. Dodd, J. M., Turnbull, D., McPhee, A. J., Deussen, A. R., Grivell, R. M., Yelland, L. N., et al. (2014). Antenatal lifestyle advice for women who are overweight or obese: LIMIT randomised trial. BMJ, 348(feb10 3), g1285–g1285.  https://doi.org/10.1136/bmj.g1285.CrossRefPubMedPubMedCentralGoogle Scholar
  14. Gavin, A. R., Thompson, E., Rue, T., & Guo, Y. (2012). Maternal early life risk factors for offspring birth weight: Findings from the Add Health Study. Prevention Science, 13(2), 162–172.  https://doi.org/10.1007/s11121-011-0253-2.CrossRefPubMedPubMedCentralGoogle Scholar
  15. Gisselmann, M. D. (2006). The influence of maternal childhood and adulthood social class on the health of the infant. Social Science & Medicine, 63(4), 1023–1033.  https://doi.org/10.1016/j.socscimed.2006.03.015.CrossRefGoogle Scholar
  16. Guo, S. (2005). Analyzing grouped data with hierarchical linear modeling. Children and Youth Services Review, 27(6), 637–652.  https://doi.org/10.1016/j.childyouth.2004.11.017.CrossRefGoogle Scholar
  17. Guttmacher, A. E., Collins, F. S., & Carmona, R. H. (2004). The family history–more important than ever. New England Journal of Medicine, 351(22), 2333–2336.  https://doi.org/10.1056/NEJMsb042979.CrossRefPubMedGoogle Scholar
  18. Harrell, F.E., Lee, K.L., & Mark, D.B. (1996). Multivariable prognostic models: Issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Statistics in Medicine, 15(4), 361–387.  https://doi.org/10.1002/(SICI)1097-0258(19960229)15:4%3C361::AID-SIM168%3E3.0.CO;2-4 CrossRefPubMedGoogle Scholar
  19. Harville, E. W., Boynton-Jarrett, R., Power, C., & Hyppönen, E. (2010). Childhood hardship, maternal smoking, and birth outcomes: A prospective cohort study. Archives of Pediatrics & Adolescent Medicine, 164(6), 533–539.  https://doi.org/10.1001/archpediatrics.2010.61.CrossRefGoogle Scholar
  20. Headen, I., Cohen, A. K., Mujahid, M., & Abrams, B. (2017). The accuracy of self-reported pregnancy-related weight: A systematic review. Obesity Reviews, 18(3), 350–369.  https://doi.org/10.1111/obr.12486.CrossRefPubMedGoogle Scholar
  21. Headen, I. E., Davis, E. M., Mujahid, M. S., & Abrams, B. (2012). Racial-ethnic differences in pregnancy-related weight. Advances in Nutrition, 3, 83–94.  https://doi.org/10.3945/an.111.000984.CrossRefPubMedPubMedCentralGoogle Scholar
  22. Johnstone, F., & Inglis, L. (1974). Familial trends in low birth weight. British Medical Journal, 3(5932), 659–661.CrossRefPubMedPubMedCentralGoogle Scholar
  23. Lawlor, D. A., Fraser, A., Macdonald-Wallis, C., Nelson, S. M., Palmer, T. M., Smith, D., G., & Tilling, K. (2011). Maternal and offspring adiposity-related genetic variants and gestational weight gain. American Journal of Clinical Nutrition, 94(1), 149–155.  https://doi.org/10.3945/ajcn.110.010751.CrossRefPubMedGoogle Scholar
  24. Li, A., Teo, K. K., Morrison, K. M., McDonald, S. D., Atkinson, S. A., Anand, S. S., & Meyre, D. (2016). A genetic link between prepregnancy body mass index, postpartum weight retention, and offspring weight in early childhood. Obesity, 25(1), 236–243.  https://doi.org/10.1093/humupd/dmp050.CrossRefPubMedGoogle Scholar
  25. Lu, M. C., Tache, V., Alexander, G. R., Kotelchuck, M., & Halfon, N. (2003). Preventing low birth weight: is prenatal care the answer? The Journal of Maternal-Fetal & Neonatal Medicine, 13(6), 362–380.  https://doi.org/10.1080/jmf.13.6.362.380.CrossRefGoogle Scholar
  26. Ludwig, D. S., & Currie, J. (2010). The association between pregnancy weight gain and birthweight: A within-family comparison. Lancet, 376(9745), 984–990.  https://doi.org/10.1016/S0140-6736(10)60751-9.CrossRefPubMedPubMedCentralGoogle Scholar
  27. Maes, H. H., Neale, M. C., & Eaves, L. J. (1997). Genetic and environmental factors in relative body weight and human adiposity. Behavior Genetics, 27(4), 325–351.CrossRefPubMedGoogle Scholar
  28. Magnus, P., Gjessing, H. K., Skrondal, A., & Skjaerven, R. (2001). Paternal contribution to birth weight. Journal of Epidemiology and Community Health, 55(12), 873–877.  https://doi.org/10.1136/jech.55.12.873.CrossRefPubMedPubMedCentralGoogle Scholar
  29. McElroy, J. J., Muglia, L. J., & Morgan, T. M. (2012). Better by the pound: the genetics of birth weight. Journal of Pediatrics, 160(1), 3–4.  https://doi.org/10.1016/j.jpeds.2011.08.064.CrossRefPubMedGoogle Scholar
  30. Rabe-Hesketh, S., & Skrondal, A. (2008). Multilevel and longitudinal modeling using Stata (2nd edn.). College Station: Stata Press.Google Scholar
  31. Rasmussen, K. M., & Yaktine, A. L. (Eds.). (2009). Weight gain during pregnancy: Reexamining the guidelines. Institute of Medicine. Washington, DC: The National Academies Press.Google Scholar
  32. Rehkopf, D. H., Krieger, N., Coull, B., & Berkman, L. F. (2010). Biologic risk markers for coronary heart disease: Nonlinear associations with income. Epidemiology, 21(1), 38–46.  https://doi.org/10.1097/EDE.0b013e3181c30b89.CrossRefPubMedGoogle Scholar
  33. Risnes, K. R., Vatten, L. J., Baker, J. L., Jameson, K., Sovio, U., Kajantie, E., et al. (2011). Birthweight and mortality in adulthood: A systematic review and meta-analysis. International Journal of Epidemiology, 40(3), 647–661.  https://doi.org/10.1093/ije/dyq267.CrossRefPubMedGoogle Scholar
  34. Robson, E. B. (1955). Birth weight in cousins. Annals of Human Genetics, 19(4), 262–268.  https://doi.org/10.1111/j.1469-1809.1955.tb01352.x.CrossRefPubMedGoogle Scholar
  35. Speakman, J. R., Levitsky, D. A., Allison, D. B., Bray, M. S., de Castro, J. M., Clegg, D. J., et al. (2011). Set points, settling points and some alternative models: theoretical options to understand how genes and environments combine to regulate body adiposity. Disease Models & Mechanisms, 4(6), 733–745.  https://doi.org/10.1242/dmm.008698.CrossRefGoogle Scholar
  36. Tyrrell, J., Richmond, R. C., Palmer, T. M., Feenstra, B., Rangarajan, J., Metrustry, S., et al. (2016). Genetic evidence for causal relationships between maternal obesity-related traits and birth weight. Journal of the American Medical Association, 315(11), 1129.  https://doi.org/10.1001/jama.2016.1975.CrossRefPubMedGoogle Scholar
  37. Waring, M. E., Simas, M., T.A., & Liao, X. (2013). Gestational weight gain within recommended ranges in consecutive pregnancies: A retrospective cohort study. Midwifery, 29(5), 550–556.  https://doi.org/10.1016/j.midw.2012.04.014.CrossRefPubMedGoogle Scholar
  38. Wilcox, A. J., & Russell, I. T. (1983). Birthweight and perinatal mortality: II. On weight-specific mortality. International Journal of Epidemiology, 12(3), 319–325.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Ellen Luecke
    • 1
  • Alison K. Cohen
    • 2
  • Miranda Brillante
    • 3
  • David H. Rehkopf
    • 4
  • Jeremy Coyle
    • 3
  • C. Emily Hendrick
    • 5
  • Barbara Abrams
    • 3
    • 6
    Email author
  1. 1.RTI International, Women’s Global Health ImperativeSan FranciscoUSA
  2. 2.Department of Public and Nonprofit AdministrationUniversity of San FranciscoSan FranciscoUSA
  3. 3.University of California Berkeley School of Public HealthBerkeleyUSA
  4. 4.Division of Primary Care and Population HealthStanford University School of MedicineStanfordUSA
  5. 5.Division of Reproduction and Population HealthUniversity of Wisconsin-Madison School of Medicine and Public HealthMadisonUSA
  6. 6.Division of EpidemiologyUC Berkeley School of Public HealthBerkeleyUSA

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