Objectives Air pollution exposure may contribute to the development of preeclampsia and hypertension during pregnancy. However, the evidence for such a relation is still limited. We investigated the associations between exposure for moderate to low levels of air pollution during pregnancy and preeclampsia and gestational hypertension in selected urban and county areas of Norway. Methods This study used a sub-group of 17,533 women in the Norwegian Mother and Child Cohort Study. Air pollution levels at residential addresses were estimated using land use regression models and back-extrapolated to the period of each pregnancy. Information on preeclampsia and gestational hypertension were obtained from the Medical Birth Registry of Norway and information on lifestyle factors was collected from questionnaires completed by the women during pregnancy. Results Moderate mean levels of NO2 (13.6 ± 6.9 µg/m3) at residential address during pregnancy were not associated with preeclampsia and pregnancy hypertension. We found no statistically significant associations per 10 µg/m3 change in NO2 exposure and preeclampsia (adjusted OR 0.89, 95% CI 0.74, 1.08) or hypertension during pregnancy (adjusted OR 0.91, 95% CI 0.78, 1.06). Conclusions for Practice In this large Norwegian pregnancy cohort, we found no statistically significant associations for moderate to low levels of pregnancy NO2 exposure and preeclampsia or hypertension during pregnancy.
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Beelen, R., Hoek, G., Vienneau, D., Eeftens, M., Dimakopoulou, K., Pedeli, X., et al. (2013). Development of NO2 and NOx land use regression models for estimating air pollution exposure in 36 study areas in Europe - The ESCAPE project. Atmospheric Environment, 72, 10–23.
Brook, R. D., Rajagopalan, S., Pope, C. A. 3rd, Bhatnagar, A., Diez-Roux, A. V., Holguin, F., et al. (2010). Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. Circulation, 121(21), 2331–2378.
Dadvand, P., Figueras, F., Basagana, X., Beelen, R., Martinez, D., Cirach, M., et al. (2013). Ambient air pollution and preeclampsia: A spatiotemporal analysis. Environmental Health Perspectives, 121(11–12), 1365–1371.
Dadvand, P., Ostro, B., Amato, F., Figueras, F., Minguillón, M. C., Martinez, D., et al. (2014). Particulate air pollution and preeclampsia: a source-based analysis. Occupational and Environmental Medicine, 71(8), 570–577.
Engel, S. M., Scher, E., Wallenstein, S., Savitz, D. A., Alsaker, E. R., Trogstad, L., et al. (2013). Maternal active and passive smoking and hypertensive disorders of pregnancy: Risk with trimester-specific exposures. Epidemiology, 24(3), 379–386.
Hu, H., Ha, S., Roth, J., Kearney, G., Talbott, E. O., & Xu, X. (2014). Ambient air pollution and hypertensive disorders of pregnancy: A systematic review and meta-analysis. Atmospheric Environment, 97, 336–345.
Klungsoyr, K., Harmon, Q. E., Skard, L. B., Simonsen, I., Austvoll, E. T., Alsaker, E. R., et al. (2014). Validity of pre-eclampsia registration in the medical birth registry of Norway for women participating in the Norwegian mother and child cohort study, 1999–2010. Paediatric and Perinatal Epidemiology, 28(5), 362–371.
Lee, P. C., Roberts, J. M., Catov, J. M., Talbott, E. O., & Ritz, B. (2013). First trimester exposure to ambient air pollution, pregnancy complications and adverse birth outcomes in Allegheny County, PA. Maternal and Child Health Journal, 17(3), 545–555.
Magnus, P., Birke, C., Vejrup, K., Haugan, A., Alsaker, E., Daltveit, A. K., et al. (2016). Cohort profile update: The Norwegian Mother and Child Cohort Study (MoBa). International Journal of Epidemiology, 45(2), 382–388.
Malmqvist, E., Jakobsson, K., Tinnerberg, H., Rignell-Hydbom, A., & Rylander, L. (2013). Gestational diabetes and preeclampsia in association with air pollution at levels below current air quality guidelines. Environmental Health Perspectives, 121(4), 488–493.
Mobasher, Z., Salam, M. T., Goodwin, T. M., Lurmann, F., Ingles, S. A., & Wilson, M. L. (2013). Associations between ambient air pollution and hypertensive disorders of pregnancy. Environmental Research, 123, 9–16.
Olsson, D., Mogren, I., & Forsberg, B. (2013) Air pollution exposure in early pregnancy and adverse pregnancy outcomes: A register-based cohort study. British Medical Journal Open 3(2), e001955
Panasevich, S., Håberg, S. E., Aamodt, G., London, S. J., Stigum, H., Nystad, W., et al. (2016). Association between pregnancy exposure to air pollution and birth weight in selected areas of Norway. Archives of Public Health, 74, 26.
Pedersen, M., Giorgis-Allemand, L., Bernard, C., Aguilera, I., Andersen, A. M., Ballester, F., et al. (2013). Ambient air pollution and low birthweight: A European Cohort Study (ESCAPE). The Lancet Respiratory Medicine, 1(9), 695–704.
Pedersen, M., Halldorsson, T. I., Olsen, S. F., Hjortebjerg, D., Ketzel, M., Grandström, C., et al. (2017). Impact of road traffic pollution on pre-eclampsia and pregnancy-induced hypertensive disorders. Epidemiology, 28(1), 99–106.
Pedersen, M., Stayner, L., Slama, R., Sørensen, M., Figueras, F., Nieuwenhuijsen, M. J., et al. (2014). Ambient air pollution and pregnancy-induced hypertensive disorders: A systematic review and meta-analysis. Hypertension, 64(3), 494–500.
Pereira, G., Haggar, F., Shand, A. W., Bower, C., Cook, A., & Nassar, N. (2013). Association between pre-eclampsia and locally derived traffic-related air pollution: a retrospective cohort study. Journal of Epidemiology and Community Health, 67(2), 147–152.
Sibai, B., Dekker, G., & Kupferminc, M. (2005). Pre-eclampsia. The Lancet, 365(9461), 785–799.
Skjaerven, R., Wilcox, A. J., & Lie, R. T. (2002). The interval between pregnancies and the risk of preeclampsia. New England Journal of Medicine, 346(1), 33–38.
Steegers, E. A., von Dadelszen, P., Duvekot, J. J., & Pijnenborg, R. (2010). Pre-eclampsia. The Lancet, 376(9741), 631–644.
van den Hooven, E. H., de Kluizenaar, Y., Pierik, F. H., van Ratingen, S. W., Zandveld, P. Y., Mackenbach, J. P., et al. (2011). Air pollution, blood pressure, and the risk of hypertensive complications during pregnancy: The generation R study. Hypertension, 57(3), 406–412.
van den Hooven, E. H., Jaddoe, V. W., de Kluizenaar, Y., Hofman, A., Mackenbach, J. P., Steegers, E. A. P., et al. (2009). Residential traffic exposure and pregnancy-related outcomes: A prospective birth cohort study. Environmental Health, 8, 59.
Wu, J., Ren, C., Delfino, R. J., Chung, J., Wilhelm, M., & Ritz, B. (2009). Association between local traffic-generated air pollution and preeclampsia and preterm delivery in the south coast air basin of California. Environmental Health Perspectives, 117(11), 1773–1779.
Xu, X., Hu, H., Ha, S., & Roth, J. (2014). Ambient air pollution and hypertensive disorder of pregnancy. Journal of Epidemiology and Community Health, 68(1), 13–20.
Yorifuji, T., Naruse, H., Kashima, S., Murakoshi, T., & Doi, H. (2015). Residential proximity to major roads and obstetrical complications. Science of The Total Environment, 508, 188–192.
The co-authors would like to express gratitude to all MoBa cohort participants and research team, to Sviatlana Panasevich and Jon Wickmann at NIPH for their help with the database management, and to the Norwegian Institute for Air Research team for providing valuable research data thru their national air quality database.
The Norwegian Mother and Child Cohort Study is supported by the Norwegian Ministry of Health and the Ministry of Education and Research, NIH/NIEHS (contract no N01-ES-75558), NIH/NIDS (grant no.1 UO1NS 047537-01 and grant no.2 UO1 NS 047537-06A1). This study was also supported by the Research Council of Norway (Grant No. 196102) and the Intramural Research Program of the NIH, National Institute of Environmental Health Sciences (Project Number Z01 ES49019).
The Norwegian Mother and Child Cohort Study has approvals from the Regional Ethics Committee and the Norwegian Data Inspectorate. The current study is based on version VI of the quality-assured data files released for research on the 15th April 2011.
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Madsen, C., Håberg, S.E., Aamodt, G. et al. Preeclampsia and Hypertension During Pregnancy in Areas with Relatively Low Levels of Traffic Air Pollution. Matern Child Health J 22, 512–519 (2018). https://doi.org/10.1007/s10995-017-2417-6
- Air pollution
- Pregnancy hypertension
- The Norwegian Mother and Child Cohort Study