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Maternal and Child Health Journal

, Volume 21, Issue 6, pp 1367–1376 | Cite as

Markers of Oxidative Stress in Human Milk do not Differ by Maternal BMI But are Related to Infant Growth Trajectories

  • Bridget E. YoungEmail author
  • Zachary W. Patinkin
  • Laura Pyle
  • Becky de la Houssaye
  • Barbara S. Davidson
  • Sheela Geraghty
  • Ardythe L. Morrow
  • Nancy Krebs
Article

Abstract

Objective Obesity in adults is associated with inflammation and oxidative stress. Whether or not this phenotype is reflected in human milk (HM) composition, or may impact infant growth remains unknown. We investigated whether HM from overweight/obese (OW/Ob) mothers exhibited higher concentrations of inflammatory cytokines and markers of oxidative stress. We also correlated these bioactive components with infant growth patterns. Methods This was an observational cohort of 56 breastfeeding mothers and their infants [33 normal weight (NW) and 23 OW/Ob]. Infants were followed until 6 months of age and HM collected at 2-weeks and 4-months. Results Markers of oxidative stress, 8-hydroxy-deoxyguanosine (8OHdG) and 4-hydroxynonenol (HNE), decreased in HM over time (p < 0.001) and did not differ between NW and OW/Ob women. Concentrations of inflammatory cytokines, IL-6, IL-8, and TNF-α, were all inter-correlated (p < 0.001) but did not differ between NW and OW/Ob women. HM fat, protein, lactose, and total calories did not differ between NW and OW/Ob women. Infant growth patterns did not differ by group. In a model of infant weight-for-length-Z score trajectory, there was a significant interaction between both lactose and 8OHdG with maternal group: HM lactose and 8OHdG concentrations were both positively associated with increases in WLZ trajectory only among infants breastfed by OW/Ob mothers. Conclusions for Practice HM composition was relatively stable between NW and OW/Ob women. In exclusively breastfed infants, HM concentrations of lactose and 8OHdG, a marker of oxidative stress, may contribute to regulation of infant weight gain, especially among infants of OW/Ob women.

Keywords

Oxidative stress Infant growth Human milk composition Maternal obesity Breastfeeding 

Abbreviations

WAZ

Weight for age Z-score

LAZ

Length for age Z-score

WLZ

Weight for length Z-score

HM

Human milk

8OHdG

8-Hydroxy-deoxyguanosine

HNE

4-Hydroxynonenol

Notes

Acknowledgements

We wish to thank the mothers and infants who participated in this research. This work was supported in part by: National Institute of Health: NIDDK T32: DK007658-21 and NIDDK K24: DK083772 and NICHD P01: HD1302; Colorado Clinical & Translational Sciences Institute (CCTSI) Child and Maternal Health Award and with the Development and Informatics Service Center (DISC) Grant support (NIH/NCRR Colorado CTSI Grant Number UL1 RR025780); and Cincinnati Clinical & Translational Sciences & Training (CCTST): Grant ULRR026314.

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Department of Pediatrics Section of NutritionUniversity of Colorado School of MedicineAuroraUSA
  2. 2.Department of Biostatistics and InformaticsUniversity of Colorado School of Public HealthAuroraUSA
  3. 3.Department of Pediatrics Section of NeonatologyUniversity of Colorado School of MedicineAuroraUSA
  4. 4.Department of Pediatrics, Center for Interdisciplinary Research in Human Milk and LactationCincinnati Children’s Hospital Medical CenterCincinnatiUSA
  5. 5.Center for Breastfeeding MedicineCincinnati Children’s Hospital Medical CenterCincinnatiUSA

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