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Association of Bisphenol A Exposure with Breastfeeding and Perceived Insufficient Milk Supply in Mexican Women

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An Erratum to this article was published on 01 July 2016

Abstract

Introduction Estrogen inhibits lactation and bisphenol A (BPA) is a high production environmental estrogen. We hypothesize an inhibitory effect of BPA on lactation and aim to analyze the association between third trimester pregnancy urinary BPA and breastfeeding rates 1 month postpartum. Methods Odds ratios (OR) and 95 % confidence intervals (95 % CI) of breastfeeding and perceived insufficient milk supply (PIM) in relation to maternal peripartum urinary BPA concentrations were calculated in 216 mothers. Results 97.2 % of mothers in the lowest BPA tertile were breastfeeding at 1 month postpartum, compared to 89.9 % in highest (p = 0.01). Adjusted ORs (95 % CI) for not breastfeeding at 1 month were 1.9 (0.3, 10.7) and 4.3 (0.8, 21.6) for second and third BPA tertiles, respectively, compared to the lowest (p = 0.06, trend). 4.2 % reported PIM in the lowest BPA tertile, compared to 8.7 % in the highest (p = 0.03). Adjusted ORs (95 % CI) for PIM were 1.8 (0.4, 7.7) and 2.2 (0.5, 9.5), for the second and third BPA tertiles, respectively, compared to the lowest (p = 0.29, trend). Discussion These results suggest an association between maternal BPA exposure and decreased breastfeeding.

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Acknowledgments

This research was supported in part by the National Institute of Environmental Health Sciences (NIEHS) and Environmental Protection Agency (EPA) Grants R01ES007821, P20 ES018171/RD83480001, P30 ES017885, P01 ES02284401/RD 83543601 and by the National Institute of Public Health, Ministry of Health, Mexico. The American British Cowdray Hospital provided the facilities used to conduct this research.

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Authors and Affiliations

  1. Department of Nutritional Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI, 48109, USA

    Nicole Kasper PhD, Karen E. Peterson ScD, Zhenzhen Zhang PhD & Adrienne S. Ettinger ScD

  2. Department of Pediatrics, Section of Nutrition, University of Colorado Anschutz Medical Campus, 13123 E. 16th Ave., Aurora, CO, 80045, USA

    Nicole Kasper PhD

  3. Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave., Boston, MA, 02115, USA

    Karen E. Peterson ScD

  4. Center for Human Growth and Development, University of Michigan, 300 N Ingalls St., Ann Arbor, MI, 48104, USA

    Karen E. Peterson ScD

  5. Department of Biostatistics, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI, 48109, USA

    Zhenzhen Zhang PhD & Brisa N. Sánchez PhD

  6. Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI, 48109, USA

    Kelly K. Ferguson PhD & John D. Meeker ScD

  7. Epidemiology Branch, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA

    Kelly K. Ferguson PhD

  8. Center for Research on Nutrition and Health, National Institute of Public Health, Universidad No. 655 Colonia Santa Maria Ahuacatitlán, Cerrada Los Pinos y Caminera, C.P. 62100, Cuernavaca, Morelos, Mexico

    Alejandra Cantoral ScD & Maria M. Téllez-Rojo PhD

  9. Brandon Newborn Intensive Care Unit, C.S. Mott Children’s Hospital, 1540 E Hospital Dr., Ann Arbor, MI, 48109, USA

    Carolyn M. Pawlowski RN

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  1. Nicole Kasper PhD
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Correspondence to Karen E. Peterson ScD.

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Kasper, N., Peterson, K.E., Zhang, Z. et al. Association of Bisphenol A Exposure with Breastfeeding and Perceived Insufficient Milk Supply in Mexican Women. Matern Child Health J 20, 1713–1719 (2016). https://doi.org/10.1007/s10995-016-1974-4

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