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Hepatitis C Seroprevalence Among HIV-Infected Childbearing Women in New York State in 2006

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Abstract

Objective To identify factors associated with maternal hepatitis C virus (HCV) seroprevalence and transmission of HCV as identified by qualitative HCV ribonucleic acid (RNA) in the infants of human immunodeficiency virus (HIV) infected women delivering in New York State (NYS) in 2006. Study Design In this retrospective cohort study of HIV-exposed infants born in NYS, leftover infant plasma from HIV diagnostic testing was de-identified and tested for HCV. If HCV antibodies were detected, a second specimen collected when the infant was >2 months old was tested for HCV qualitative RNA. Multivariate logistic regression was used to identify factors associated with HCV seropositivity. Results In a final sample of 553 live birth events with perinatal HIV exposure, 21 (3.8 %) of tested infant specimens had HCV antibodies indicative of maternal HCV seropositivity. Maternal age at delivery of >35 years, Hispanic ethnicity, white race and injection drug use (IDU) were significantly associated with HCV seropositivity in multivariate analysis. No cases of HCV vertical transmission were identified among HCV exposed infant specimens. Conclusions This statewide population-based study of HIV-infected childbearing women shows HCV seroprevalence of 3.8 %. Maternal age of >35 years and IDU are the strongest predictors of HCV seropositivity. Although no viral transmission was documented, more comprehensive longitudinal testing would be required to conclude that HCV transmission did not occur.

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Abbreviations

HCV:

Hepatitis C virus

HIV:

Human immunodeficiency virus

IDU:

Injection drug use

NHANES:

National Health and Nutrition Examination Survey

NYS:

New York State

NYSDOH:

New York State Department of Health

RNA:

Ribonucleic acid

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Authors and Affiliations

  1. Surveillance and Special Projects Unit, Bureau of STD Prevention and Epidemiology, AIDS Institute, New York State Department of Health, ESP, Corning Tower, Albany, NY, 12237, USA

    L. Ghazaryan

  2. Division of Epidemiology, Evaluation and Research, New York State Department of Health, Corning Tower, ESP, Albany, NY, 12237, USA

    L. Smith & W. Pulver

  3. Bloodborne Viruses Laboratory, Wadsworth Center, New York State Department of Health, 120 New Scotland Avenue, Albany, NY, 12208, USA

    M. Parker

  4. Viral Hepatitis Section, AIDS Institute, New York State Department of Health, ESP, Corning Tower Room 429, Albany, NY, 12237, USA

    C. Flanigan

  5. Wadsworth Center, New York State Department of Health, 120 New Scotland Avenue, Albany, NY, 12208, USA

    T. Sullivan

  6. Cancer Control, American Cancer Society, Eastern Division, One Penny Lane, Latham, NY, 12110, USA

    A. Carrascal

Authors
  1. L. Ghazaryan
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  2. L. Smith
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  3. M. Parker
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  4. C. Flanigan
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  5. W. Pulver
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  6. T. Sullivan
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  7. A. Carrascal
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Correspondence to L. Ghazaryan.

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Ghazaryan, L., Smith, L., Parker, M. et al. Hepatitis C Seroprevalence Among HIV-Infected Childbearing Women in New York State in 2006. Matern Child Health J 20, 550–555 (2016). https://doi.org/10.1007/s10995-015-1853-4

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  • DOI: https://doi.org/10.1007/s10995-015-1853-4

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