Maternal and Child Health Journal

, Volume 18, Issue 4, pp 873–881 | Cite as

Six-Month Outcomes from a Randomized Controlled Trial to Prevent Perinatal Depression in Low-Income Home Visiting Clients

  • S. Darius TandonEmail author
  • Julie A. Leis
  • Tamar Mendelson
  • Deborah F. Perry
  • Karen Kemp


Perinatal depression (PD) has negative consequences for mothers and children and is more prevalent among women of low socioeconomic status. Home visitation programs serve low-income pregnant women at risk for PD. This study tested the efficacy of a group-based cognitive behavioral intervention (Mothers and Babies Course; MB) in reducing depressive symptoms and preventing the onset of perinatal depression among low-income women enrolled in home visitation. A randomized controlled trial was conducted. Seventy-eight women who were pregnant or had a child less than 6 months of age and who were assessed as at risk for PD were randomized to the MB intervention or usual home visiting services. Depressive symptoms were assessed at baseline and 1-week, 3- and 6-months post-intervention; depressive episodes were assessed with a clinical interview at the 6-month follow-up. Depressive symptoms declined at a significantly greater rate for intervention participants than usual care participants between baseline and 1-week, 3 and 6 months post-intervention. At the 6-month follow-up, 15 % of women who received the MB intervention had experienced a major depressive episode as compared with 32 % of women receiving usual care. Integrating mental health interventions into home visitation appears to be a promising approach for preventing PD. Cognitive behavioral techniques can be effective in preventing depression in perinatal populations and treating it.


Perinatal depression Depression Prevention Home visiting African American Low-income 



The study was funded by a grant (UL1 RR025005) from the National Center for Research Resources (NCRR) at the National Institutes of Health, as part of a consortium of Clinical and Translational Science Awards (CTSA). We would also like to thank the four home visiting programs and their program participants for their strong support of this project.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • S. Darius Tandon
    • 1
    Email author
  • Julie A. Leis
    • 1
  • Tamar Mendelson
    • 2
  • Deborah F. Perry
    • 3
  • Karen Kemp
    • 1
  1. 1.Department of PediatricsJohns Hopkins University School of MedicineBaltimoreUSA
  2. 2.Johns Hopkins University Bloomberg School of Public HealthBaltimoreUSA
  3. 3.Georgetown UniversityWashingtonUSA

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