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Risk for Elevated Blood Lead Levels in 3- and 4-Year-Old Children

Maternal and Child Health Journal volume 13, pages 40–47 (2009)Cite this article

Abstract

Objective We conducted a study to evaluate the relation between environmental, demographic, and medical risk factors and late-onset childhood lead poisoning, defined as children who were poisoned at age 3 or older. Methods We performed a retrospective case–control study of 262 children whose test results showed non-elevated (<10 μg/dl) blood lead levels (BLLs) before age 2 but levels ≥10 μg/dl after age 3 and of 300 control children who had non-elevated BLL test results before age 2 and also after age 3. The target population was children receiving care at MetroHealth Medical Center in Cleveland, OH. We modeled the association between demographic and clinical risk factors and BLLs ≥10 μg/dl after age 3. Covariates considered were race, gender, body mass index, immunization status, mean corpuscular volume, hematocrit, red cell volume distribution width (RDW), red blood count, hemoglobin, baseline BLL result, and time between the baseline and second BLL test. Results Case children were more likely to be male (P < 0.0001), black (P = 0.0189) and to have a high RDW defined as ≥14.5 % (P = 0.0083). On the basis of the final model, children with BLLs 7–9 μg/dl before age 2 and again after a follow-up BLL test (<21 months) were more likely to become lead poisoned than were control children. The risk of black children developing lead poisoning increased over time, regardless of the child’s first BLL test result. Conclusions Although national recommendations are to test children’s blood lead levels at ages 1 and 2, children living in high-risk areas with such risk factors should have a blood lead test at these older ages.

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Affiliations

  1. Lead Poisoning Prevention Branch, Division of Emergency and Environmental Health Services, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy., MS: F-40, Atlanta, GA, 30341, USA

    Jaime S. Raymond, David Homa & Mary Jean Brown

  2. MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH, 44109, USA

    Roberta Anderson & Mark Feingold

Authors
  1. Jaime S. Raymond
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  2. Roberta Anderson
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  3. Mark Feingold
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  4. David Homa
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  5. Mary Jean Brown
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Correspondence to Jaime S. Raymond.

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Jaime S. Raymond and Roberta Anderson contributed equally to this work.

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Raymond, J.S., Anderson, R., Feingold, M. et al. Risk for Elevated Blood Lead Levels in 3- and 4-Year-Old Children. Matern Child Health J 13, 40–47 (2009). https://doi.org/10.1007/s10995-007-0297-x

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  • DOI: https://doi.org/10.1007/s10995-007-0297-x

Keywords

  • Childhood lead poisoning
  • Late onset lead poisoning
  • Case control study
  • Clinical risk factors