Vaspin Exert Anti-Inflammatory and Antioxidant Effects on Renal and Liver Injury Induced by Renal Ischemia Reperfusion

Abstract

Renal ischemia–reperfusion (IR) is a common cause of acute renal failure and result in remote organ injury. Oxidative stress and inflammation are of the suggested causes of renal IR injury. The aim of the present study was to investigate the protective effects of vaspin as an adipokine on renal and liver injury after renal IR. 36 Male mice randomly assigned to four groups: (1) Sham operated (2) renal IR (45 min bilateral ischemia) (3 & 4) renal IR + vaspin (20 & 40 mg/kg). Animals were intragastrically administered with PBS (Sham) or vaspin (20 & 40 mg/kg) for 7 days before renal IR. Renal IR induced renal functional damage, oxidative stress and inflammation in kidney and liver. Treatment with vaspin decreased plasma BUN, creatinine, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) and increased creatinine clearance and urine flow rate. In both renal and liver tissues a significant rise in superoxide dismutase, catalase, interleukin-10 and fall in Malondialdehyde and tumor necrosis factor-α were seen after treatment. Oral administration of vaspin diminished renal and hepatic functional injury, oxidative stress and inflammation.

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Correspondence to Hossein Khastar.

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Salehi, M., Garmabi, B., Jafarisani, M. et al. Vaspin Exert Anti-Inflammatory and Antioxidant Effects on Renal and Liver Injury Induced by Renal Ischemia Reperfusion. Int J Pept Res Ther 26, 1607–1612 (2020). https://doi.org/10.1007/s10989-019-09973-6

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Keywords

  • Renal ischemia–reperfusion
  • Vaspin
  • Adipokine
  • Oxidative stress
  • Inflammation
  • Remote organ injury