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Central Opioidergic and Adrenergic systems Mediates Food Intake via α1, α2 and β2 Receptors in Neonatal Layer-Type Chicken

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Abstract

The aim of the current study was to determine possible interaction of central Opioidergic and Adrenergic systems on food intake regulation in neonatal layer-type chicken. In experiment 1, chicken ICV injected with control solution, DAMGO (µopioid receptors agonist, 125 pmol), parazosin (α1 receptor antagonist, 10 nmol) and DAMGO + parazosin. In experiment 2, control solution, DAMGO (125 pmol), yohimbine (α2 receptor antagonist, 13 nmol) and DAMGO + yohimbine were ICV injected. In experiment 3, FD3 birds ICV injected with control solution, DAMGO (125 pmol), metoprolol (β1 receptor antagonist, 24 nmol) and DAMGO + metoprolol. In experiment 4, FD3 chicks received ICV injection of control solution, DAMGO (125 pmol), ICI 118,551 (β2 receptor antagonist, 5 nmol) and DAMGO + ICI 118,551. Experiments 5–8 were similar to experiments 1–4, except chicken injected with DPDPE (δ opioid receptors agonist, 40 nmol) instead of DAMGO. Experiments 9–12 were similar to experiments 1–4, except chicken injected with U-50488H (κ opioid receptors agonist, 30 nmol) instead of DAMGO. Then, cumulative food intake was recorded at 30, 60 and 120 min after injection. According to the results, ICV injection of the DAMGO significantly decreased food intake while DPDPE and U-50488H significantly increased food intake in neonatal layer type chicken (P < 0.05). Co-injection of the DAMGO + ICI 118,551 decreased DAMGO-induced hypophagia (P < 0.05). Also, co-injection of the DPDPE + parazosin diminished hyperphagic effect of the DPDPE (P < 0.05). In addition, co-injection of the U-50488H + yohimbine diminished U-50488H-induced hyperphagia (P < 0.05). These results suggested there are interconnection between adrenergic and opioidergic systems on central food intake regulation which mediates via α1, α2 and β2 receptors in neonatal layer-type chicken.

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References

  • Allgaier C, Daschmann B, Sieverling J, Hertting G (1989) Presynaptic κ-opioid receptors on noradrenergic nerve terminals couple to G proteins and interact with the α2-adrenoceptors. J Neurochem 53:1629–1635

    CAS  PubMed  Google Scholar 

  • Andrade CAF, Andrade GMF, De Luca Jr LA, Colombari DSA, Menani JV (2007) Interactions between serotoninergic, α2-adrenergic, gabaergic and opioidergic mechanisms of the lateral parabrachial nucleus in the control of NaCl intake. Appetite 49:272–341

    Google Scholar 

  • Baghbanzadeh A, Hajinezhad MR, Shohreh B, Maleklou R (2010) Intralateral hypothalamic area injection of isoproterenol and propranolol affects food and water intake in broilers. J Comp Physiol A 196:221–226

    CAS  Google Scholar 

  • Benyhe S, Zádor F, Ötvös F (2015) Biochemistry of opioid (morphine) receptors: binding, structure and molecular modeling. Acta Biol Szeged 59(Suppl.1):17–37

    Google Scholar 

  • Blevins JE, Stanley BG, Reidelberger RD (2002) DMSO as a vehicle for central injections: tests with feeding elicited by norepinephrine injected into the paraventricular nucleus. Pharmacol Biochem Behav 71:277–282

    CAS  PubMed  Google Scholar 

  • Bungo T, Shimojo M, Masuda Y, Choi YH, Denbow DM, Furuse M (1999) Induction of food intake by a noradrenergic system using clonidine and fusaric acid in the neonatal chick. Brain Res 826:313–316

    CAS  PubMed  Google Scholar 

  • Bungo T, Kawamura K, Izumi T, Dodo K, Ueda H (2005) Effects of various µ-, δ- and κ-opioid ligands on food intake in the meat-type chick. Physiol Behav 85:519–523

    CAS  PubMed  Google Scholar 

  • Bungo T, Dodo KI, Izumi T (2007) Central injection of endomorphin-2, but not endomorphin-1, increases food intake in chicks via µ1-opioid receptors. J Poult Sci 44:205–208

    CAS  Google Scholar 

  • Chabot-Doré AJ, Schuster DJ, Stone LS, Wilcox GL (2015) Analgesic synergy between opioid and α2-adrenoceptors. Br J Pharmacol 172:388–402

    PubMed  Google Scholar 

  • Crowley NA, Kash TL (2015) Kappa opioid receptor signaling in the brain: Circuitry and implications for treatment. Prog Neuro-Psychopharmacol Biol Psychiatry 62:51–60

    CAS  Google Scholar 

  • da Silva ES, Flores RA, Ribas AS, Taschetto AP, Faria MS, Lima LB, Metzger M, Donato J Jr, Paschoalini MA (2017) Injections of the of the α1-adrenoceptor antagonist prazosin into the median raphe nucleus increase food intake and Fos expression in orexin neurons of free-feeding rats. Behav Brain Res 324:87–95

    PubMed  Google Scholar 

  • Davis JL, Masuoka DT, Gerbrandt LK, Cherkin A (1979) Autoradiographic distribution of L-proline in chicks after intracerebral injection. Physiol Behav 22:693–695

    CAS  PubMed  Google Scholar 

  • Denbow DM (1994) Peripheral regulation of food intake in poultry. J Nutr 124:1349S–1354S

    CAS  PubMed  Google Scholar 

  • Denbow DM (1999) Food intake regulation in birds. J Exp Zool 283:333–338

    Google Scholar 

  • Denbow DM, Sheppard BJ (1993) Food and water intake responses of the domestic fowl to norepinephrine infusion at circumscribed neural sites. Brain Res Bull 31:121–128

    CAS  PubMed  Google Scholar 

  • Denbow DM, Cherry JA, Siegel PB, Van Kery HP (1981) Eating, drinking and temperature response of chicks to brain catecholamine injections. Physiol Behav 27:265–269

    CAS  PubMed  Google Scholar 

  • Dodo K, Izumi T, Bungo H T (2005) Response of neuropeptide Y-induced feeding to µ-, δ-Ueda and κ-opioid receptor antagonists in the neonatal chick. Neurosci Lett 373:85–88

    CAS  PubMed  Google Scholar 

  • Feng Y, He X, Yang Y, Chao D, Lazarus LH, Xia Y (2012) Current research on opioid receptor function. Curr Drug Targets 13(2):230–246

    CAS  PubMed  PubMed Central  Google Scholar 

  • Filizola M, Devi LA (2013) Grand opening of structure-guided design for novel opioids. Trends Pharmacol Sci 34(1):6–12

    CAS  PubMed  Google Scholar 

  • Fukui M, Nakagawa T, Minami M, Satoh M (2001) Involvement of β2-adrenergic and µ-opioid receptors in antinociception produced by intracerebroventricular administration of α,β-methylene-ATP. Jpn J Pharmacol 86:423–428

    CAS  PubMed  Google Scholar 

  • Furuse M, Matsumoto M, Saito N, Sugahara K, Hasegava S (1997) The central corticotropin-releasing factor and glucagon-like peptide-1 in food intake of the neonatal chick. EurJ Pharmacol 339:211–214

    CAS  Google Scholar 

  • Furuse M, Ando R, Bungo T, Ao R, ShimoJO M, Masuda Y (1999) Intracerebroventricular injection of orexins does not stimulate food intake in neonatal chicks. Br Poult Sci 40:698–700

    CAS  PubMed  Google Scholar 

  • Hassanpour S, Zendehdel M, Babapour V, Charkhkar S (2015) Endocannabinoid and nitric oxide interaction mediates food intake in neonatal chicken. Br Poult Sci 56(4):443–451

    CAS  PubMed  Google Scholar 

  • Jonaidi H, Noori Z (2012) Neuropeptide Y-induced feeding is dependent on GABAA receptors in neonatal chicks. J Comp Physiol A 198:827–832

    CAS  Google Scholar 

  • Kaneko K, Yoshikawa M, Ohinata K (2012) Novel orexigenic pathway prostaglandin D2-NPY system-Involvement in orally active orexigenic δ opioid peptide. Neuropeptides 46:353–357

    CAS  PubMed  Google Scholar 

  • Kanzler SA, Januario AC, Paschoalini MA (2011) Involvement of β3 -adrenergic receptors in the control of food intake in rats. Braz J Med Biol Res 44(11):1141–1147

    CAS  PubMed  Google Scholar 

  • Lei S (2014) Cross interaction of dopaminergic and adrenergicsystems in neural modulation. Int J Physiol Pathophysiol Pharmacol 6(3):137–142

    CAS  PubMed  PubMed Central  Google Scholar 

  • Manglik A, Kruse AC, Kobilka TS, Thian FS, Mathiesen JM, Sunahara RK, Pardo L, Weis WI, Kobilka BK, Granier S (2012) Crystal structure of the µ-opioid receptor bound to a morphinan antagonist. Nature 485:321–326

    CAS  PubMed  PubMed Central  Google Scholar 

  • Olanrewaju HA, Purswell J, Collier SD, Branton SL (2017) Effects of light ingress through ventilation fan apertures on selected blood variables of male broilers. Int J Poult Sci 16:288–295

    CAS  Google Scholar 

  • Parker KE, Johns HW, Floros TG, Will MJ (2014) Central amygdala opioid transmission is necessary for increased high-fat intake following 24-h food deprivation, but not following intra-accumbens opioid administration. Behav Brain Res 260:131–138

    CAS  PubMed  Google Scholar 

  • Qi W, Ding D, Salvi RJ (2008) Cytotoxic effects of dimethyl sulphoxide (DMSO) on cochlear organotypic cultures. Hear Res 236:52–60

    CAS  PubMed  Google Scholar 

  • Ramanathan R, Cryer PE (2011) Adrenergic mediation of hypoglycemia-associated autonomic failure. Diabetes 60(2):602–606

    CAS  PubMed  PubMed Central  Google Scholar 

  • Richards MP (2003) Genetic regulation of feed intake and energy balance in poultry. Poult Sci 82:907–916

    CAS  PubMed  Google Scholar 

  • Root-Bernstein R, Turke M, Subhramanyam UKT, Churchill B, Labahn J (2018) Adrenergic agonists bind to adrenergic-receptor- like regions of the mu opioid receptor, enhancing morphine and methionine-enkephalin binding: a new approach to “Biased Opioids”? Int J Mol Sci 19:272. https://doi.org/10.3390/ijms19010272

    Article  CAS  PubMed Central  Google Scholar 

  • Rozenfeld R, Devi LA (2011) Exploring a role for heteromerization in GPCR signaling specificity. Biochem J 433:11–18

    CAS  PubMed  Google Scholar 

  • Saito ES, Kaiya H, Tachibana T, Denbow DM, Kangawa K, Furuse M (2005) Inhibitory effect of ghrelin on food intake is mediated by the corticotropin-releasing factor system in neonatal chicks. Regul Pept 125:201–208

    CAS  PubMed  Google Scholar 

  • Sharkey KA, Darmani NA, Parker LA (2014) Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system. Eur J Pharmacol 722:134–146

    CAS  PubMed  Google Scholar 

  • Shojaei M, Zendehdel M, Babapour V, Charkhkar S, Hassanpour S (2015) Opioid-induced hypophagia is mediated by 5-HT2c receptors in neonatal layer-type chicken. Czech J Anim Sci 60(9):400–410

    CAS  Google Scholar 

  • Tachibana T, Sugahara K, Ueda H, Cline MA (2009) Role of adrenergic alpha-2-receptors on feeding behavior in layer-type chicks. Gen Comp Endocrinol 161:407–411

    CAS  PubMed  Google Scholar 

  • Tan M, Walwyn WM, Evans CJ, Xie CW (2009) -Arrestin 2 mediate functional interactions between endogenous bp38 map kinase and 2A-adrenergic receptors in neurons. J Biol Chem 284(10):6270–6281

    CAS  PubMed  PubMed Central  Google Scholar 

  • Trujillo KA, Smith ML, Guaderrama MM (2011) Powerful behavioral interactions between methamphetamine and morphine. Pharmacol Biochem Behav 99:451–458

    CAS  PubMed  PubMed Central  Google Scholar 

  • Tsujii S, Bray GA (1998) A beta-3 adrenergic agonist (BRL-37,344) decreases food intake. Physiol Behav 63:723–728

    CAS  PubMed  Google Scholar 

  • Van Tienhoven A, Juhasz LP (1962) The chicken telencephalon, diencephalon and mesencephalon in sterotaxic coordinates. J Comp Neurol 118:185–197

    Google Scholar 

  • Wellman PJ (1992) Overview of adrenergic anorectic agents. Am J Clin Nutr 55(1):193S–198S

    CAS  PubMed  Google Scholar 

  • Yanagita K, Shiraishi J, Fujita M, Bungo T (2008) Effects of N-terminal fragments of β-endorphin on feeding in chicks. Neurosci Lett 442:140–142

    CAS  PubMed  Google Scholar 

  • Zendehdel M, Hassanpour S (2014) Ghrelin-induced hypophagia is mediated by the β2 adrenergic receptor in chicken. J Physiol Sci 64:383–391

    CAS  PubMed  Google Scholar 

  • Zendehdel M, Ghashghayi E, Hassanpour S, Baghbanzadeh A, Jonaidi H (2016) Interaction between opioidergic and dopaminergic systems on food intake in neonatal layer type chicken. Int J Pept Res Ther 22:83–92

    CAS  Google Scholar 

  • Zendehdel M, Parvizi Z, Hassanpour S, Baghbanzadeh A, Hamidi F (2017) Interaction between nociceptin/orphanin FQ and adrenergic system on food intake in neonatal chicken. Int J Pept Res Ther 23:155–161

    CAS  Google Scholar 

  • Zheng H, Patterson LM, Berthoud HR (2007) Orexin signaling in the ventral tegmental area is required for high-fat appetite induced by opioid stimulation of the nucleus accumbens. J Neurosci 27:11075–11082

    CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

The authors thank the central laboratory (Dr. Rastegar Lab.) of the Faculty of Veterinary Medicine, University of Tehran for cooperation. This research is conducted as a part of the PhD thesis of the first author.

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Authors and Affiliations

  1. Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Neda Nayebzadeh & Bita Vazir

  2. Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, 14155-6453, Iran

    Morteza Zendehdel

  3. Department of Clinical Science, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Ahamd Asghari

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  1. Neda Nayebzadeh
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  2. Bita Vazir
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  3. Morteza Zendehdel
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Correspondence to Bita Vazir.

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Nayebzadeh, N., Vazir, B., Zendehdel, M. et al. Central Opioidergic and Adrenergic systems Mediates Food Intake via α1, α2 and β2 Receptors in Neonatal Layer-Type Chicken. Int J Pept Res Ther 26, 1–10 (2020). https://doi.org/10.1007/s10989-019-09810-w

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