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Interaction Between Central Oxytocinergic and Glutamatergic Systems on Food Intake in Neonatal Chicks: Role of NMDA and AMPA Receptors

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Abstract

The present study was designed to examine the interconnection between oxytocinergic and glutamatergic systems on feeding behavior in neonatal chicks. In experiment 1, FD3 chicken ICV injected with (A) saline (control solution), (B) oxytocin (10 µg), (C) MK-801(NMDA receptor antagonist, 15 nmol) and (D) oxytocin + MK-801. In experiment 2, (A) control solution, (B) oxytocin (10 µg), (C) CNQX (390 nmol) and (D) oxytocin + CNQX were injected. Experiments 3–6 were similar to experiment 1, except FD3 chicks ICV injected with CNQX (AMPA glutamate receptors antagonist, 390 nmol), AIDA (mGLUR1 glutamate receptors antagonist, 2 nmol), LY341495 (mGLUR2 glutamate receptors antagonist, 150 nmol) and UBP1112 (mGLUR3 glutamate receptors antagonist, 2 nmol) instead of MK-801, respectively. In experiment 7, injections were (A) control solution, (B) glutamate (300 nmol), (C) ABN-297 (9 nmol) and (D) glutamate + ABN-297. Then the cumulative food intake measured until 120 min post injection. According to the results, ICV injection of glutamate decreased food intake and co-injection of the glutamate + ABN-297 increased food consumption in neonatal broiler (P < 0.001). ICV injection of oxytocin, significantly decreased food intake in neonatal chicks (P < 0.001). Also, MK-801 significantly attenuated oxytocin- induced hypophagia in chicks (P < 0.001). In addition, combination of oxytocin plus CNQX significantly decreased hypophagic effect of the oxytocin in neonatal chicks (P < 0.001). These results suggested interconnection between central oxytocinergic and glutamatergic systems on feeding behavior is probably mediated via NMDA and AMPA receptors.

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Acknowledgements

The authors thank the central laboratory (Dr. Rastegar Lab.) of the Faculty of Veterinary Medicine, University of Tehran for cooperation. This research is conducted as a part of the PhD thesis of the first author.

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Authors and Affiliations

  1. Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Mohammadsaber Jalali & Hasan Gilanpour

  2. Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, 14155-6453, Iran

    Morteza Zendehdel & Vahab Babapour

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  1. Mohammadsaber Jalali
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  2. Morteza Zendehdel
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  3. Vahab Babapour
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  4. Hasan Gilanpour
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Correspondence to Morteza Zendehdel.

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This manuscript does not contain any studies with human subjects performed by any of the authors.

Research Involving Human and Animal Rights

All experiments were executed according to the Guide for the Care and Use of Laboratory Animals and were approved by the institutional animal ethics committee.

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Jalali, M., Zendehdel, M., Babapour, V. et al. Interaction Between Central Oxytocinergic and Glutamatergic Systems on Food Intake in Neonatal Chicks: Role of NMDA and AMPA Receptors. Int J Pept Res Ther 25, 195–203 (2019). https://doi.org/10.1007/s10989-017-9664-7

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