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A Review of the Salivary Proteome and Peptidome and Saliva-derived Peptide Therapeutics

  • N. Laila Huq
  • Keith J. Cross
  • Men Ung
  • Helen Myroforidis
  • Paul D. Veith
  • Dina Chen
  • David Stanton
  • Huiling He
  • Brent R. Ward
  • Eric C. ReynoldsEmail author
Special Issue: Peptides in Oral and Dental Research

Abstract

Saliva is a glandular secretion that is vital in the maintenance of healthy oral tissues. In this review we outline the high abundance salivary proteins, summarise the status of the salivary proteome and peptidome, the genetic origin and recognised functions of these proteins, the diseases associated with salivary disorders, and the emerging saliva-derived peptide therapeutics. Different proteomic approaches have reported the identification of over 1,300 proteins in saliva. However there are fewer than 100 high abundance proteins, identified by multiple methods including, two-dimensional polyacrylamide gel electrophoresis and HPLC combined with mass spectrometry. Analysis of the genes coding for the salivary proteins demonstrated a non-uniform chromosomal distribution with chromosome 4 having the largest proportion of genes expressed in salivary glands. Several diseases are associated with salivary disorders including Sjögren’s syndrome, Prader-Willi syndrome, dental caries and stress related disorders. Saliva as a diagnostic medium for various biochemical tests has provided a non-invasive and accessibility advantage over other more regularly tested body fluids such as blood and urine. To-date the emerging saliva-based therapeutics include artificial salivas and antimicrobial agents based on histatins and mucins.

Keywords

Saliva Proteome Peptidome Peptide therapeutics 

Notes

Acknowledgement

We wish to acknowledge the contribution of Priscilla Lu who was a recipient of an ADRF summer scholarship.

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • N. Laila Huq
    • 1
  • Keith J. Cross
    • 1
  • Men Ung
    • 1
  • Helen Myroforidis
    • 1
  • Paul D. Veith
    • 1
  • Dina Chen
    • 1
  • David Stanton
    • 1
  • Huiling He
    • 1
  • Brent R. Ward
    • 1
  • Eric C. Reynolds
    • 1
    Email author
  1. 1.Cooperative Research Centre for Oral Health Science, School of Dental Science, Bio21 InstituteThe University of MelbourneMelbourneAustralia

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