Abstract
A doubly censoring scheme occurs when the lifetimes T being measured, from a well-known time origin, are exactly observed within a window [L, R] of observational time and are otherwise censored either from above (right-censored observations) or below (left-censored observations). Sample data consists on the pairs (U, δ) where U = min{R, max{T, L}} and δ indicates whether T is exactly observed (δ = 0), right-censored (δ = 1) or left-censored (δ = −1). We are interested in the estimation of the marginal behaviour of the three random variables T, L and R based on the observed pairs (U, δ). We propose new nonparametric simultaneous marginal estimators \({\hat S_{T}, \hat S_{L}}\) and \({\hat S_{R}}\) for the survival functions of T, L and R, respectively, by means of an inverse-probability-of-censoring approach. The proposed estimators \({\hat S_{T}, \hat S_{L}}\) and \({\hat S_{R}}\) are not computationally intensive, generalize the empirical survival estimator and reduce to the Kaplan-Meier estimator in the absence of left-censored data. Furthermore, \({\hat S_{T}}\) is equivalent to a self-consistent estimator, is uniformly strongly consistent and asymptotically normal. The method is illustrated with data from a cohort of drug users recruited in a detoxification program in Badalona (Spain). For these data we estimate the survival function for the elapsed time from starting IV-drugs to AIDS diagnosis, as well as the potential follow-up time. A simulation study is discussed to assess the performance of the three survival estimators for moderate sample sizes and different censoring levels.
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Julià, O., Gómez, G. Simultaneous marginal survival estimators when doubly censored data is present. Lifetime Data Anal 17, 347–372 (2011). https://doi.org/10.1007/s10985-010-9186-5
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DOI: https://doi.org/10.1007/s10985-010-9186-5