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Generalized log-gamma regression models with cure fraction

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Abstract

In this paper, the generalized log-gamma regression model is modified to allow the possibility that long-term survivors may be present in the data. This modification leads to a generalized log-gamma regression model with a cure rate, encompassing, as special cases, the log-exponential, log-Weibull and log-normal regression models with a cure rate typically used to model such data. The models attempt to simultaneously estimate the effects of explanatory variables on the timing acceleration/deceleration of a given event and the surviving fraction, that is, the proportion of the population for which the event never occurs. The normal curvatures of local influence are derived under some usual perturbation schemes and two martingale-type residuals are proposed to assess departures from the generalized log-gamma error assumption as well as to detect outlying observations. Finally, a data set from the medical area is analyzed.

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References

  • Barlow WE, Prentice RL (1988) Residual for relative risk regression. Biometrika 75: 65–74

    Article  MATH  MathSciNet  Google Scholar 

  • Berkson J, Gage RP (1952) Survival curve for cancer patients following treatment. J Am Statist Assoc 88: 1412–1418

    Google Scholar 

  • Chen M-H, Ibrahim JG, Sinha D (1999) A new Bayesian model for survival data with a surviving fraction. J Am Statist Assoc 94: 909–919

    Article  MATH  MathSciNet  Google Scholar 

  • Cook RD (1986) Assessment of local influence (with discussion). J R Statist Soc 48: 133–169

    MATH  Google Scholar 

  • Cook RD, Weisberg S (1982) Residuals and influence in regression. Chapman and Hill, New York

    MATH  Google Scholar 

  • Cooner F, Banerjee S, Carlin BP, Sinha D (2007) Flexible cure rate modeling under latent activation schemes. J Am Statist Assoc 102: 560–572

    Article  MATH  MathSciNet  Google Scholar 

  • de Castro AFM, Cancho VG, Rodrigues J (2007) A flexible model for survival data with a surviving fraction. Technical Report n 0 173, Department of Statistics, Univesidade Federal de São Carlos, Brazil

  • Díaz-Garcia JA, Galea M, Leiva-Sanchez V (2004) Influence diagnostics for elliptical multivariate linear regression models. Commun Statist—Theory Methods 32: 625–641

    Article  Google Scholar 

  • Doornik J (2001) Ox: an object-oriented matrix programming language. International Thompson Business Press, London

    Google Scholar 

  • Escobar LA, Meeker WQ (1992) Assessing influence in regression analysis with censored data. Biometrics 48: 507–528

    Article  MATH  MathSciNet  Google Scholar 

  • Fleming TR, Harrington DP (1991) Counting process and survival analysis. Wiley, New York

    Google Scholar 

  • Galea M, Riquelme M, Paula GA (2000) Diagnostics methods in elliptical linear regression models. Braz J Probab Statist 14: 167–184

    MATH  MathSciNet  Google Scholar 

  • Hoggart C, Griffin JE (2001) A Bayesian partition model for customer attrition. In: George EI (ed) Bayesian methods with applications to science, policy, and official statistics (Selected papers from ISBA 2000). International Society for Bayesian Analysis, Creta, pp 61–70

  • Ibrahim JG, Chen MH, Sinha D (2001) Bayesian survival analysis. Springer-Verlag, New York

    MATH  Google Scholar 

  • Kalbfleisch JD, Prentice RL (1980) The statistical analysis of failure time data. Wiley, New York

    MATH  Google Scholar 

  • Lawless JF (2003) Statistical models and methods for lifetime data. Wiley, New York

    MATH  Google Scholar 

  • Le SY, Lu B, Song XY (2006) Assessing local influence for nonlinear structural equation models with ignorable missing data. Comput Statist Data Anal 50: 1356–1377

    Article  MathSciNet  Google Scholar 

  • Lesaffre E, Verbeke G (1998) Local influence in linear mixed models. Biometrics 54: 570–582

    Article  MATH  Google Scholar 

  • Li CS, Taylor JMG, Sy JP (2001) Identifiability of cure models. Statist Probab Lett 54: 389–395

    Article  MATH  MathSciNet  Google Scholar 

  • Maller R, Zhou X (1996) Survival analysis with long-term survivors. Wiley, New York

    MATH  Google Scholar 

  • McCullagh P, Nelder JA (1989) Generalized linear models, 2nd edn. Chapman and Hall, London

    MATH  Google Scholar 

  • Ortega EMM (2001) Influence analysis and residual in generalized log-gamma regression models. Doctoral Thesis, Department of Statistics, University of São Paulo, Brasil (in Portuguese)

  • Ortega EMM, Bolfarine H, Paula GA (2003) Influence diagnostics in generalized log-gamma regression models. Comput Statist Data Anal 42: 165–186

    Article  MATH  MathSciNet  Google Scholar 

  • Ortega EMM, Cancho VG, Bolfarine H (2006) Influence diagnostics in exponentiated-Weibull regression models with censored data. Statist Oper Res Trans 30: 171–192

    MathSciNet  Google Scholar 

  • Ortega EMM, Paula GA, Bolfarine H (2008) Deviance residuals in generalized log-Gamma regression models with censored observations. J Statist Comput Simul 78: 747–768

    Article  MATH  Google Scholar 

  • Pettitt AN, Bin Daud I (1989) Case-weight measures of influence for proportional hazards regression. Appl Statist 38: 51–67

    Article  Google Scholar 

  • Prentice RL (1974) A log-gamma model and its maximum likelihood estimation. Biometrica 61: 539–544

    Article  MATH  MathSciNet  Google Scholar 

  • Silva GO, Ortega EMM, Garibay VC, Barreto ML (2008) Log-Burr XII regression models with censored Data. Comput Statist Data Anal 52: 3820–3842

    Article  MATH  MathSciNet  Google Scholar 

  • Stacy EW (1962) A generalization of the gamma distribution. Ann Math Statist 33: 1187–1192

    Article  MATH  MathSciNet  Google Scholar 

  • Therneau TM, Grambsch PM, Fleming TR (1990) Martingale-based residuals for survival models. Biometrika 77: 147–160

    Article  MATH  MathSciNet  Google Scholar 

  • Tsodikov AD, Ibrahim JG, Yakovlev AY (2003) Estimating cure rates from survival data: an alternative to two-component mixture models. J Am Statist Assoc 98: 1063–1078

    Article  MathSciNet  Google Scholar 

  • Yakovlev A, Tsodikov AD (1996) Stochastic models of tumor latency and their biostatistical applications. Mathematical biology and medicine, vol 1. World Scientific, NJ

    Google Scholar 

  • Yamaguchi K (1992) Accelerated failure-time regression models with a regression model of surviving fraction: an application to the analysis of “permanent employment” in Japan. J Am Statist Assoc 87: 284–292

    Article  Google Scholar 

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Correspondence to Edwin M. M. Ortega.

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Ortega, E.M.M., Cancho, V.G. & Paula, G.A. Generalized log-gamma regression models with cure fraction. Lifetime Data Anal 15, 79–106 (2009). https://doi.org/10.1007/s10985-008-9096-y

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