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Pair Chart Test for an Early Survival Difference

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Abstract

The log-rank test is commonly used in comparing survival distributions between treatment and control groups in clinical trials. However, in many studies, the treatment is only effective at the early stage of the trial. Especially when the two survival curves cross, the log-rank test has a low statistical power to show the survival difference. We propose a test statistic for detecting such an early difference between the two treatment arms. The new test has an intuitive geometric interpretation based on a pair chart and is shown to have more power than the log-rank test when the treatment effect only appears in the early phase of the study. This advantage is evaluated for finite sample sizes in simulation studies. Finally, the proposed method is illustrated with a real data example of patients with gastric cancer.

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Authors and Affiliations

  1. Department of Biostatistics, M. D. Anderson Cancer Center, The University of Texas, Texas, USA

    Guosheng Yin

  2. Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, USA

    Donglin Zeng

Authors
  1. Guosheng Yin
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  2. Donglin Zeng
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Correspondence to Guosheng Yin.

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Yin, G., Zeng, D. Pair Chart Test for an Early Survival Difference. Lifetime Data Anal 11, 117–129 (2005). https://doi.org/10.1007/s10985-004-5643-3

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  • DOI: https://doi.org/10.1007/s10985-004-5643-3

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