Abstract
Melatonin (N-acetyl-5-methoxy-tryptamine) is an effective antioxidant and free radical scavenger, that has important biological effects in multiple cell types and species. Melatonin research in muscle has recently gained attention, mainly focused on its role in cells or tissue repair and regeneration after injury, due to its powerful biological functions, including its antioxidant, anti-inflammation, anti-tumor and anti-cancer, circadian rhythm, and anti-apoptotic effects. However, the effect of melatonin in regulating muscle development has not been systematically summarized. In this review, we outline the latest research on the involvement of melatonin in the regulation of muscle development and regeneration in order to better understand its underlying molecular mechanisms and potential applications.
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References
Agil A, Elmahallawy EK, Rodriguez-Ferrer JM, Adem A, Bastaki SM, Al-Abbadi I et al (2015) Melatonin increases intracellular calcium in the liver, muscle, white adipose tissues and pancreas of diabetic obese rats. Food Funct 6(8):2671–2678. https://doi.org/10.1039/c5fo00590f
Alonso M, Collado PS, Gonzalez-Gallego J (2006) Melatonin inhibits the expression of the inducible isoform of nitric oxide synthase and nuclear factor kappa B activation in rat skeletal muscle. J Pineal Res 41(1):8–14. https://doi.org/10.1111/j.1600-079X.2006.00323.x
Ambrosio F, Kadi F, Lexell J, Fitzgerald GK, Boninger ML, Huard J (2009) The effect of muscle loading on skeletal muscle regenerative potential: an update of current research findings relating to aging and neuromuscular pathology. Am J Phys Med Rehabil 88(2):145–155. https://doi.org/10.1097/PHM.0b013e3181951fc5
Arushanian EB, Schetinin EV (2016) Melatonin as a universal modulator of any pathological processes. Patol Fiziol Eksp Ter 60(1):79–88
Bi W, Bi Y, Xue P, Zhang Y, Gao X, Wang Z, Bi L (2010) Synthesis and characterization of novel indole derivatives reveal improved therapeutic agents for treatment of ischemia/reperfusion (I/R) injury. J Med Chem 53(18):6763–6767. https://doi.org/10.1021/jm100529e
Borges Lda S, Dermargos A, da Silva Junior EP, Weimann E, Lambertucci RH, Hatanaka E (2015) Melatonin decreases muscular oxidative stress and inflammation induced by strenuous exercise and stimulates growth factor synthesis. J Pineal Res 58(2):166–172. https://doi.org/10.1111/jpi.12202
Brack AS, Rando TA (2012) Tissue-specific stem cells: lessons from the skeletal muscle satellite cell. Cell Stem Cell 10(5):504–514. https://doi.org/10.1016/j.stem.2012.04.001
Carpentieri A, Diaz de Barboza G, Areco V, Lopez P, de TolosaTalamoni N (2012) New perspectives in melatonin uses. Pharmacol Res 65(4):437–444. https://doi.org/10.1016/j.phrs.2012.01.003
Chahbouni M, Escames G, Venegas C, Sevilla B, Garcia JA, Lopez LC, Acuna-Castroviejo D (2010) Melatonin treatment normalizes plasma pro-inflammatory cytokines and nitrosative/oxidative stress in patients suffering from Duchenne muscular dystrophy. J Pineal Res 48(3):282–289. https://doi.org/10.1111/j.1600-079X.2010.00752.x
Cheung TH, Rando TA (2013) Molecular regulation of stem cell quiescence. Nat Rev Mol Cell Biol 14(6):329–340. https://doi.org/10.1038/nrm3591
Collins CA, Olsen I, Zammit PS, Heslop L, Petrie A, Partridge TA, Morgan JE (2005) Stem cell function, self-renewal, and behavioral heterogeneity of cells from the adult muscle satellite cell niche. Cell 122(2):289–301. https://doi.org/10.1016/j.cell.2005.05.010
Coto-Montes A, Boga JA, Tan DX, Reiter RJ (2016) Melatonin as a potential agent in the treatment of sarcopenia. Int J Mol Sci.https://doi.org/10.3390/ijms17101771
Dauchy RT, Blask DE, Sauer LA, Davidson LK, Krause JA, Smith LC, Dauchy EM (2003) Physiologic melatonin concentration, omega-3 fatty acids, and conjugated linoleic acid inhibit fatty acid transport in rodent hind limb skeletal muscle in vivo. Comp Med 53(2):186–190
de Almeida-Paula LD, Costa-Lotufo LV, Silva Ferreira Z, Monteiro AE, Isoldi MC, Godinho RO, Markus RP (2005) Melatonin modulates rat myotube-acetylcholine receptors by inhibiting calmodulin. Eur J Pharmacol 525(1–3):24–31. https://doi.org/10.1016/j.ejphar.2005.09.056
Diekman MA, Clapper JA, Green ML, Stouffer DK (1991) Reduction in age of puberty in gilts consuming melatonin during decreasing or increasing daylength. J Anim Sci 69(6):2524–2531. https://doi.org/10.2527/1991.6962524x
Duda GN, Taylor WR, Winkler T, Matziolis G, Heller MO, Haas NP, Schaser KD (2008) Biomechanical, microvascular, and cellular factors promote muscle and bone regeneration. Exerc Sport Sci Rev 36(2):64–70. https://doi.org/10.1097/JES.0b013e318168eb88
Erdem M, Bostan B, Gunes T, Ozkan F, Sen C, Ozyurt H, Erdogan H (2010) Protective effects of melatonin on ischemia-reperfusion injury of skeletal muscle. Eklem Hastalik Cerrahisi 21(3):166–171
Erkanli K, Kayalar N, Erkanli G, Ercan F, Sener G, Kirali K (2005) Melatonin protects against ischemia/reperfusion injury in skeletal muscle. J Pineal Res 39(3):238–242. https://doi.org/10.1111/j.1600-079X.2005.00240.x
Favero G, Rodella LF, Nardo L, Giugno L, Cocchi MA, Borsani E, Rezzani R (2015) A comparison of melatonin and alpha-lipoic acid in the induction of antioxidant defences in L6 rat skeletal muscle cells. Age (Dordr) 37(4):9824. https://doi.org/10.1007/s11357-015-9824-7
Favero G, Trapletti V, Bonomini F, Stacchiotti A, Lavazza A, Rodella LF, Rezzani R (2017) Oral supplementation of melatonin protects against fibromyalgia-related skeletal muscle alterations in reserpine-induced myalgia rats. Int J Mol Sci.https://doi.org/10.3390/ijms18071389
Favero G, Bonomini F, Franco C, Rezzani R (2019) Mitochondrial dysfunction in skeletal muscle of a fibromyalgia model: the potential benefits of melatonin. Int J Mol Sci.https://doi.org/10.3390/ijms20030765
Ferreira DS, Amaral FG, Mesquita CC, Barbosa AP, Lellis-Santos C, Turati AO, Anhe GF (2012) Maternal melatonin programs the daily pattern of energy metabolism in adult offspring. PLoS ONE 7(6):e38795. https://doi.org/10.1371/journal.pone.0038795
Ha E, Yim SV, Chung JH, Yoon KS, Kang I, Cho YH, Baik HH (2006) Melatonin stimulates glucose transport via insulin receptor substrate-1/phosphatidylinositol 3-kinase pathway in C2C12 murine skeletal muscle cells. J Pineal Res 41(1):67–72. https://doi.org/10.1111/j.1600-079X.2006.00334.x
Halevy O, Piestun Y, Allouh MZ, Rosser BW, Rinkevich Y, Reshef R, Yablonka-Reuveni Z (2004) Pattern of Pax7 expression during myogenesis in the posthatch chicken establishes a model for satellite cell differentiation and renewal. Dev Dyn 231(3):489–502. https://doi.org/10.1002/dvdy.20151
Halici M, Narin F, Turk CY, Saraymen R, Baykan A, Kabak S (2004) The effect of melatonin on plasma oxidant-antioxidant skeletal muscle reperfusion injury in rats. J Int Med Res 32(5):500–506. https://doi.org/10.1177/147323000403200507
Hara M, Abe M, Suzuki T, Reiter RJ (1996) Tissue changes in glutathione metabolism and lipid peroxidation induced by swimming are partially prevented by melatonin. Pharmacol Toxicol 78(5):308–312
Hara M, Iigo M, Ohtani-Kaneko R, Nakamura N, Suzuki T, Reiter RJ, Hirata K (1997) Administration of melatonin and related indoles prevents exercise-induced cellular oxidative changes in rats. Biol Signals 6(2):90–100
Hibaoui Y, Roulet E, Ruegg UT (2009) Melatonin prevents oxidative stress-mediated mitochondrial permeability transition and death in skeletal muscle cells. J Pineal Res 47(3):238–252. https://doi.org/10.1111/j.1600-079X.2009.00707.x
Hibaoui Y, Reutenauer-Patte J, Patthey-Vuadens O, Ruegg UT, Dorchies OM (2011) Melatonin improves muscle function of the dystrophic mdx5Cv mouse, a model for Duchenne muscular dystrophy. J Pineal Res 51(2):163–171. https://doi.org/10.1111/j.1600-079X.2011.00871.x
Hong Y, Kim JH, Jin Y, Lee S, Park K, Lee Y, Hong Y (2014) Melatonin treatment combined with treadmill exercise accelerates muscular adaptation through early inhibition of CHOP-mediated autophagy in the gastrocnemius of rats with intra-articular collagenase-induced knee laxity. J Pineal Res 56(2):175–188. https://doi.org/10.1111/jpi.12110
Kennaway DJ, Owens JA, Voultsios A, Varcoe TJ (2006) Functional central rhythmicity and light entrainment, but not liver and muscle rhythmicity, are clock independent. Am J Physiol Regul Integr Comp Physiol 291(4):R1172–R1180. https://doi.org/10.1152/ajpregu.00223.2006
Kim CH, Kim KH, Yoo YM (2012) Melatonin-induced autophagy is associated with degradation of MyoD protein in C2C12 myoblast cells. J Pineal Res 53(3):289–297. https://doi.org/10.1111/j.1600-079X.2012.00998.x
Kuang S, Kuroda K, Le Grand F, Rudnicki MA (2007) Asymmetric self-renewal and commitment of satellite stem cells in muscle. Cell 129(5):999–1010. https://doi.org/10.1016/j.cell.2007.03.044
Kurhaluk N, Szarmach A, Zaitseva OV, Sliuta A, Kyriienko S, Winklewski PJ (2018) Effects of melatonin on low-dose lipopolysaccharide-induced oxidative stress in mouse liver, muscle, and kidney. Can J Physiol Pharmacol 96(11):1153–1160. https://doi.org/10.1139/cjpp-2018-0011
Lamosova D, Zeman M, Jurani M (1997) Influence of melatonin on chick skeletal muscle cell growth. Comp Biochem Physiol C 118(3):375–379
Le Grand F, Rudnicki MA (2007) Skeletal muscle satellite cells and adult myogenesis. Curr Opin Cell Biol 19(6):628–633. https://doi.org/10.1016/j.ceb.2007.09.012
Lee S, Shin J, Hong Y, Lee M, Kim K, Lee SR, Hong Y (2012) Beneficial effects of melatonin on stroke-induced muscle atrophy in focal cerebral ischemic rats. Lab Anim Res 28(1):47–54. https://doi.org/10.5625/lar.2012.28.1.47
Lee JY, Kim JH, Lee DC (2014) Urine melatonin levels are inversely associated with sarcopenia in postmenopausal women. Menopause 21(1):39–44. https://doi.org/10.1097/GME.0b013e318291f6c8
Leonardo-Mendonca RC, Ocana-Wilhelmi J, de Haro T, de Teresa-Galvan C, Guerra-Hernandez E, Rusanova I, Acuna-Castroviejo D (2017) The benefit of a supplement with the antioxidant melatonin on redox status and muscle damage in resistance-trained athletes. Appl Physiol Nutr Metab 42(7):700–707. https://doi.org/10.1139/apnm-2016-0677
Lepper C, Partridge TA, Fan CM (2011) An absolute requirement for Pax7-positive satellite cells in acute injury-induced skeletal muscle regeneration. Development 138(17):3639–3646. https://doi.org/10.1242/dev.067595
Lopez LC, Escames G, Tapias V, Utrilla P, Leon J, Acuna-Castroviejo D (2006) Identification of an inducible nitric oxide synthase in diaphragm mitochondria from septic mice: its relation with mitochondrial dysfunction and prevention by melatonin. Int J Biochem Cell Biol 38(2):267–278. https://doi.org/10.1016/j.biocel.2005.09.008
Luchetti F, Canonico B, Bartolini D, Arcangeletti M, Ciffolilli S, Murdolo G, Galli F (2014) Melatonin regulates mesenchymal stem cell differentiation: a review. J Pineal Res 56(4):382–397. https://doi.org/10.1111/jpi.12133
Maarman GJ, Reiter RJ (2018) Melatonin therapy for blunt trauma and strenuous exercise: a mechanism involving cytokines, NFkappaB, Akt, MAFBX and MURF-1. J Sports Sci 36(16):1897–1901. https://doi.org/10.1080/02640414.2018.1424491
Maarman GJ, Andrew BM, Blackhurst DM, Ojuka EO (2017) Melatonin protects against uric acid-induced mitochondrial dysfunction, oxidative stress, and triglyceride accumulation in C2C12 myotubes. J Appl Physiol 122(4):1003–1010. https://doi.org/10.1152/japplphysiol.00873.2016
Majidinia M, Reiter RJ, Shakouri SK, Mohebbi I, Rastegar M, Kaviani M, Yousefi B (2018) The multiple functions of melatonin in regenerative medicine. Ageing Res Rev 45:33–52. https://doi.org/10.1016/j.arr.2018.04.003
Mazepa RC, Cuevas MJ, Collado PS, Gonzalez-Gallego J (2000) Melatonin increases muscle and liver glycogen content in nonexercised and exercised rats. Life Sci 66(2):153–160
Mehanna RA, Soliman GY, Hassaan PS, Sharara GM, Abdel-Moneim RA (2017) Protective role of melatonin on skeletal muscle injury in rats. Int J Clin Exp Med 10(1):1490–1501
Mendes C, Lopes AM, Amaral do, Peliciari-Garcia FG, Ade RA T, Hirabara O, Cipolla-Neto SM (2013) Adaptations of the aging animal to exercise: role of daily supplementation with melatonin. J Pineal Res 55(3):229–239. https://doi.org/10.1111/jpi.12065
Mero AA, Vahalummukka M, Hulmi JJ, Kallio P, von Wright A (2006) Effects of resistance exercise session after oral ingestion of melatonin on physiological and performance responses of adult men. Eur J Appl Physiol 96(6):729–739. https://doi.org/10.1007/s00421-005-0119-z
Montarras D, Morgan J, Collins C, Relaix F, Zaffran S, Cumano A, Buckingham M (2005) Direct isolation of satellite cells for skeletal muscle regeneration. Science 309(5743):2064–2067. https://doi.org/10.1126/science.1114758
Murphy MM, Lawson JA, Mathew SJ, Hutcheson DA, Kardon G (2011) Satellite cells, connective tissue fibroblasts and their interactions are crucial for muscle regeneration. Development 138(17):3625–3637. https://doi.org/10.1242/dev.064162
Navarro-Alarcon M, Ruiz-Ojeda FJ, Blanca-Herrera RM, Acuna-Castroviejo MM AS, Fernandez-Vazquez D, Agil A (2014) Melatonin and metabolic regulation: a review. Food Funct 5(11):2806–2832. https://doi.org/10.1039/c4fo00317a
Obayashi K, Saeki K, Maegawa T, Iwamoto J, Sakai T, Otaki N, Kurumatani N (2016) Melatonin Secretion and Muscle Strength in Elderly Individuals: a cross-sectional study of the HEIJO-KYO cohort. J Gerontol A 71(9):1235–1240. https://doi.org/10.1093/gerona/glw030
Olguin HC, Olwin BB (2004) Pax-7 up-regulation inhibits myogenesis and cell cycle progression in satellite cells: a potential mechanism for self-renewal. Dev Biol 275(2):375–388. https://doi.org/10.1016/j.ydbio.2004.08.015
Oner J, Ozan E (2003) Effects of melatonin on skeletal muscle of rats with experimental hyperthyroidism. Endocr Res 29(4):445–455
Oner J, Oner H, Sahin Z, Demir R, Ustunel I (2008) Melatonin is as effective as testosterone in the prevention of soleus muscle atrophy induced by castration in rats. Anat Rec (Hoboken) 291(4):448–455. https://doi.org/10.1002/ar.20659
Ostjen CA, Rosa CGS, Hartmann RM, Schemitt EG, Colares JR, Marroni NP (2019) Anti-inflammatory and antioxidant effect of melatonin on recovery from muscular trauma induced in rats. Exp Mol Pathol 106:52–59. https://doi.org/10.1016/j.yexmp.2018.12.001
Park K, Lee Y, Park S, Lee S, Hong Y, Lee K, Hong Y (2010) Synergistic effect of melatonin on exercise-induced neuronal reconstruction and functional recovery in a spinal cord injury animal model. J Pineal Res 48(3):270–281. https://doi.org/10.1111/j.1600-079X.2010.00751.x
Park S, Lee SK, Park K, Lee Y, Hong Y, Lee S, Hong Y (2012) Beneficial effects of endogenous and exogenous melatonin on neural reconstruction and functional recovery in an animal model of spinal cord injury. J Pineal Res 52(1):107–119. https://doi.org/10.1111/j.1600-079X.2011.00925.x
Quan X, Wang J, Liang C, Zheng H, Zhang L (2015) Melatonin inhibits tunicamycin-induced endoplasmic reticulum stress and insulin resistance in skeletal muscle cells. Biochem Biophys Res Commun 463(4):1102–1107. https://doi.org/10.1016/j.bbrc.2015.06.065
Rateb EE, Amin SN, El-Tablawy N, Rashed LA, El-Attar S (2017) Effect of melatonin supplemented at the light or dark period on recovery of sciatic nerve injury in rats. EXCLI J 16:138–150. https://doi.org/10.17179/excli2016-763
Rezzani R, Favero G, Stacchiotti A, Rodella LF (2013) Endothelial and vascular smooth muscle cell dysfunction mediated by cyclophylin A and the atheroprotective effects of melatonin. Life Sci 92(17–19):875–882. https://doi.org/10.1016/j.lfs.2012.11.011
Rodriguez MI, Escames G, Lopez LC, Garcia JA, Ortiz F, Lopez A, Acuna-Castroviejo D (2007) Melatonin administration prevents cardiac and diaphragmatic mitochondrial oxidative damage in senescence-accelerated mice. J Endocrinol 194(3):637–643. https://doi.org/10.1677/JOE-07-0260
Sag CM, Kohler AC, Anderson ME, Backs J, Maier LS (2011) CaMKII-dependent SR Ca leak contributes to doxorubicin-induced impaired Ca handling in isolated cardiac myocytes. J Mol Cell Cardiol 51(5):749–759. https://doi.org/10.1016/j.yjmcc.2011.07.016
Sahnoun Z, Chaker-Krichen S, Kassis M, Hakim A, Hammami S, Ghozzi H, Rebai T (2007) Investigation of the microcirculation and the state of oxidative stress in the rat after scorpion envenomation. Clin Exp Pharmacol Physiol 34(4):263–268. https://doi.org/10.1111/j.1440-1681.2007.04542.x
Salucci S, Baldassarri V, Canonico B, Burattini S, Battistelli M, Guescini M, Falcieri E (2016) Melatonin behavior in restoring chemical damaged C2C12 myoblasts. Microsc Res Tech 79(6):532–540. https://doi.org/10.1002/jemt.22663
Salucci S, Battistelli M, Baldassarri V, Burini D, Falcieri E, Burattini S (2017) Melatonin prevents mitochondrial dysfunctions and death in differentiated skeletal muscle cells. Microsc Res Tech 80(11):1174–1181. https://doi.org/10.1002/jemt.22914
Sambasivan R, Yao R, Kissenpfennig A, Van Wittenberghe L, Paldi A, Gayraud-Morel B, Galy A (2011) Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration. Development 138(17):3647–3656. https://doi.org/10.1242/dev.067587
Sartori C, Dessen P, Mathieu C, Monney A, Bloch J, Nicod P, Duplain H (2009) Melatonin improves glucose homeostasis and endothelial vascular function in high-fat diet-fed insulin-resistant mice. Endocrinology 150(12):5311–5317. https://doi.org/10.1210/en.2009-0425
Sokolovic DT, Lilic L, Milenkovic V, Stefanovic R, Ilic TP, Mekic B, Ilic IR (2018) Effects of melatonin on oxidative stress parameters and pathohistological changes in rat skeletal muscle tissue following carbon tetrachloride application. Saudi Pharm J 26(7):1044–1050. https://doi.org/10.1016/j.jsps.2018.05.013
Srivastava RK, Krishna A (2010) Melatonin modulates glucose homeostasis during winter dormancy in a vespertilionid bat, Scotophilus heathi. Comp Biochem Physiol A 155(3):392–400. https://doi.org/10.1016/j.cbpa.2009.12.006
Stratos I, Richter N, Rotter R, Li Z, Zechner D, Mittlmeier T, Vollmar B (2012) Melatonin restores muscle regeneration and enhances muscle function after crush injury in rats. J Pineal Res 52(1):62–70. https://doi.org/10.1111/j.1600-079X.2011.00919.x
Teodoro BG, Baraldi FG, Sampaio IH, Bomfim LH, Queiroz AL, Passos MA, Vieira E (2014) Melatonin prevents mitochondrial dysfunction and insulin resistance in rat skeletal muscle. J Pineal Res 57(2):155–167. https://doi.org/10.1111/jpi.12157
Wang YX, Rudnicki MA (2011) Satellite cells, the engines of muscle repair. Nat Rev Mol Cell Biol 13(2):127–133. https://doi.org/10.1038/nrm3265
Wang WZ, Fang XH, Stephenson LL, Baynosa RC, Khiabani KT, Zamboni WA (2005) Microcirculatory effects of melatonin in rat skeletal muscle after prolonged ischemia. J Pineal Res 39(1):57–65. https://doi.org/10.1111/j.1600-079X.2005.00215.x
Wang WZ, Fang XH, Stephenson LL, Khiabani KT, Zamboni WA (2006) Melatonin reduces ischemia/reperfusion-induced superoxide generation in arterial wall and cell death in skeletal muscle. J Pineal Res 41(3):255–260. https://doi.org/10.1111/j.1600-079X.2006.00361.x
Wang WZ, Fang XH, Stephenson LL, Zhang X, Khiabani KT, Zamboni WA (2011) Melatonin attenuates I/R-induced mitochondrial dysfunction in skeletal muscle. J Surg Res 171(1):108–113. https://doi.org/10.1016/j.jss.2010.01.019
Yeung HM, Hung MW, Fung ML (2008) Melatonin ameliorates calcium homeostasis in myocardial and ischemia-reperfusion injury in chronically hypoxic rats. J Pineal Res 45(4):373–382. https://doi.org/10.1111/j.1600-079X.2008.00601.x
Yilmaz S, Yilmaz E (2006) Effects of melatonin and vitamin E on oxidative-antioxidative status in rats exposed to irradiation. Toxicology 222(1–2):1–7. https://doi.org/10.1016/j.tox.2006.02.008
Zammit PS, Golding JP, Nagata Y, Hudon V, Partridge TA, Beauchamp JR (2004) Muscle satellite cells adopt divergent fates: a mechanism for self-renewal? J Cell Biol 166(3):347–357. https://doi.org/10.1083/jcb.200312007
Zanuto R, Siqueira-Filho MA, Caperuto LC, Bacurau RF, Hirata E, Peliciari-Garcia RA, Carvalho CR (2013) Melatonin improves insulin sensitivity independently of weight loss in old obese rats. J Pineal Res 55(2):156–165. https://doi.org/10.1111/jpi.12056
Zencirci SG, Bilgin MD, Yaraneri H (2010) Electrophysiological and theoretical analysis of melatonin in peripheral nerve crush injury. J Neurosci Methods 191(2):277–282. https://doi.org/10.1016/j.jneumeth.2010.07.008
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The project was partially supported by the National Natural Science Foundation of China (31722053), the Natural Science Foundation of Zhejiang Province (LR17C170001) and the National Natural Science Foundation of China (31672427) to TZS.
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BC designed the study, generated the figures, and wrote the paper. WY collected, selected, and analyzed the information and data of eligible studies. TZS checked the paper. All authors read and approved the final manuscript.
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Chen, B., You, W. & Shan, T. The regulatory role of melatonin in skeletal muscle. J Muscle Res Cell Motil 41, 191–198 (2020). https://doi.org/10.1007/s10974-020-09578-3
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DOI: https://doi.org/10.1007/s10974-020-09578-3