Journal of Muscle Research and Cell Motility

, Volume 28, Issue 6, pp 355–362 | Cite as

Specific correlations between muscle oxidative stress and chronic fatigue syndrome: a working hypothesis

  • Stefania Fulle
  • Tiziana Pietrangelo
  • Rosa Mancinelli
  • Raoul Saggini
  • Giorgio FanòEmail author
Review Paper


Chronic fatigue syndrome (CFS) is a relatively common disorder defined as a status of severe persistent disabling fatigue and subjective unwellness. While the biological basis of the pathology of this disease has recently been confirmed, its pathophysiology remains to be elucidated. Moreover, since the causes of CFS have not been identified, treatment programs are directed at symptom relief, with the ultimate goal of the patient regaining some level of pre-existing function and well-being. Several studies have examined whether CFS is associated with: (i) a range of infectious agents and or immune disturbance; (ii) specific changes of activity in the central or peripheral nervous systems; and (iii) elevated stress periods, which may be associated with the pathology via genetic mechanisms. The role of oxidative stress in CFS is an emerging focus of research due to evidence of its association with some pathological features of this syndrome. New data collectively support the presence of specific critical points in the muscle that are affected by free radicals and in view of these considerations, the possible role of skeletal muscle oxidative imbalance in the genesis of CFS is discussed.


Oxidative Stress E-C coupling Chronic fatigue syndrome 


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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Stefania Fulle
    • 1
    • 2
    • 3
  • Tiziana Pietrangelo
    • 1
    • 2
    • 3
  • Rosa Mancinelli
    • 1
    • 2
    • 3
  • Raoul Saggini
    • 2
    • 3
  • Giorgio Fanò
    • 1
    • 2
    • 3
    Email author
  1. 1.Ce.S.I.—Center for Research on AgeingUniversità “G. d’Annunzio”Chieti-PescaraItaly
  2. 2.IIM—Interuniversitary Institute of MiologyUniversità “G. d’Annunzio”Chieti-PescaraItaly
  3. 3.Department of Basic and Applied Medical Science (B.A.M.S.)Università “G. d’Annunzio”Chieti-PescaraItaly

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