Abstract
To assure correct patient care and lower pharmaceutical mistakes that might cause serious harm or death, this research introduces a microfluidic heating flowmeter for tracking injectable pumping based on a mechanically pulsating heat exchanger. It is impossible to use the usual gravimetric approach for flow-rate measurement in clinics because it necessitates extensive preparations and laboratory equipment. Consequently, there is a huge need for a standard technique substitute that can be used for distant, frequent, small-scale infusion-pump surveillance. Here, to give precise measurements, the research presents a downsized heated flowmeter made of a silicon platform, a platinum heating layer atop a silicon dioxide thin membrane, and polymer microchannels. A microfluidics temperature compensation and tracking method is suggested in this research. Based on this architecture, the research put forth a heat transmission concept in which the researchers looked at the regional correlations among the macro-scale temperature detector and the microscale liquids. The accuracy of temperature management for microscale reagents was demonstrated using a series of temperature-sensitive nucleic acid multiplication experiments. The efficacy of the heat transport model is further confirmed by comparisons of mathematical and empirical data. The isothermal multiplication polymerase chain reaction temperature-related minor fluctuations in fluorescence intensity could be identified with the aid of the compensatory method that was given. If the amplifying temperature differs by 1 °C, the likelihood density plots of fluorescence intensity are significantly different from one another. This technique is useful for micro–macro-interaction monitoring generally and extends beyond microfluidic purposes.
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Acknowledgements
Magda Abd El-Rahman extends their appreciation to the Deanship of Scientific Research at King Khalid University, Abha, Saudi Arabia, for funding this work through Large Groups Project under grant number RGP 2/69/44.
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Sankad, G.C., Priyadarsini, G.D., El-Rahman, M.A. et al. Microfluidics temperature compensation and tracking for drug injection based on mechanically pulsating heat exchanger. J Therm Anal Calorim 148, 12059–12070 (2023). https://doi.org/10.1007/s10973-023-12520-7
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DOI: https://doi.org/10.1007/s10973-023-12520-7