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Constant rate thermal analysis study of a trihydrate calcium atorvastatin and effect of grinding on its thermal stability

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Abstract

The pathways of dehydration reaction of both calcium atorvastatin trihydrate (CAT) and grinded CAT were investigated using CRTA technique under controlled residual water vapor pressure of 5 hPa using complementary analysis techniques, namely TG, DSC and XRD. The results show that the studied sample is a pure atorvastatin in its trihydrated form and that, under CRTA conditions, it dehydrates in three separated steps between 261 and 393 K, each corresponds to the loss of one water molecule. On the other hand, the grinded CAT dehydrates in one step. From the duration of the CRTA experiment and the X-ray diffraction technique, we have showed that the grinding partially dehydrates CAT, to obtain calcium atorvastatin 1.5 H2O, while decreasing its crystallinity. Also, examination by X-ray diffraction technique of the CRTA final products of both, CAT and grinded CAT, showed that the anhydrous phase of CAT is crystallized, whereas the one of the grinded CAT is amorphous. The apparent activation energies corresponding to the dehydration steps of intact CAT (39 kJ mol−1 and 34 kJ mol−1) and grinded CAT (126 kJ mol−1 and 289 kJ mol−1) were obtained by means of two CRTA curves realized at two different reaction rates without any hypothesis on the kinetic model of the reaction.

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Funding

Funding is provided by Ministère de l’Enseignement Supérieur et de la Recherche Scientifique.

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Authors and Affiliations

  1. Laboratory of Application of Chemistry to Resources and Natural Substances and to the Environment, Faculty of Sciences of Bizerte, University of Carthage, 7021, Zarzouna, Tunisia

    Nadia Meddeb & Kais Nahdi

  2. Materials Physics Laboratory, Department of Physics, Gebze Technical University, 41400, Kocaeli, Turkey

    Abdelhakim Elmhamdi & Mahmut Aksit

  3. Laboratoire des Matériaux, Traitement et Analyse (LMTA), Institut National de Recherche et d’Analyse Physico-Chimique, Technopole Sidi Thabet, 2020, Ariana, Tunisia

    Haykel Galai

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  1. Nadia Meddeb
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Meddeb, N., Elmhamdi, A., Aksit, M. et al. Constant rate thermal analysis study of a trihydrate calcium atorvastatin and effect of grinding on its thermal stability. J Therm Anal Calorim 148, 11425–11433 (2023). https://doi.org/10.1007/s10973-023-12510-9

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