Abstract
The temperature dependence of the pair and triplet interaction between aromatic amino acid L-Tryptophan (Trp) and glycerol (Gl) or urea (U) in an aqueous medium was studied. For this goal, the enthalpies of solution of Trp in the water-Gl and water-U mixtures were determined in the temperature range of 298.15–328.15 K. The heat capacity values of amino acid solution as well as the partial molal heat capacities were calculated. The virial enthalpic coefficients of pair (Gl–Trp or U–Trp) and triple (Gl–Gl–Trp or U–U–Trp) interactions in aqueous solution were also computed in terms of the excess function concept. The results obtained were used to analyze the solute-non-electrolyte interactions in a liquid phase and their possible influence on stability of protein macromolecules.
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Acknowledgements
The authors dedicate this article to the memory of OAA, whose scientific work was related to the study of amino acid solutions.
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Batov, D.V., Kustov, A.V. & Smirnova, N.L. The temperature effect on the thermodynamics of the interaction of l-Tryptophan with urea and glycerol in water. J Therm Anal Calorim 148, 5521–5527 (2023). https://doi.org/10.1007/s10973-023-12056-w
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DOI: https://doi.org/10.1007/s10973-023-12056-w