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Preliminary study for preparation and characterization of medicated jelly based on Ibuprofen or Ambroxol

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Abstract

The objectives of the present investigation were to formulate and evaluate medicated oral jellies containing Ambroxol HCl, which is the most used mucolytic agent in the treatment of chronic bronchitis and formulate and evaluate medicated oral jellies containing Ibuprofen which is recognized as a nonsteroidal anti-inflammatory drug. Medicated jellies with Amb or Ibu contain the following gelling agents: gelatin (Gel), sodium alginate (Alg), pectin (Pec). Prior to jellies preparation, a compatibility study was performed for each moist binary mixture between Ibu or Amb, with each medicated jelly preparation component. Active substances, moist binary mixtures, and medicated jellies were analyzed using FTIR-UATR and thermogravimetry (TGA).

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Author notes

  1. Mădălina Mateescu and Mihaela Maria Budiul have contributed equally.

Authors and Affiliations

  1. Research Centre for Thermal Analysis in Environmental Problems, West University of Timișoara, Pestalozzi Street 16, 300115, Timișoara, România

    Mădălina Mateescu, Gabriela Vlase, Mihaela Maria Budiul, Bianca Denisa Cernuşcă & Titus Vlase

  2. West University of Timisoara - ICAM - Advanced Environmental Research Institute, Str. Oituz no. 4, RO300086, Timișoara, România

    Mădălina Mateescu, Mihaela Maria Budiul & Titus Vlase

Authors
  1. Mădălina Mateescu
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  2. Gabriela Vlase
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  3. Mihaela Maria Budiul
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  4. Bianca Denisa Cernuşcă
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  5. Titus Vlase
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Contributions

Conceptualization, GV, TV, MM and MMB; data curation, TV and GV; formal analysis, MMB, MM and TV; investigation, GV, MM, BDC, MMB and TV; methodology, GV, and TV; software, TV; supervision GV and TV; validation, TV and MMB; visualization, BDC and TV; writing-original draft, MM, GV, MMB, TV; writing-review and editing, GV, TV, and MM All authors have read and agreed to the published version of the manuscript.

Corresponding author

Correspondence to Gabriela Vlase.

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Mateescu, M., Vlase, G., Budiul, M.M. et al. Preliminary study for preparation and characterization of medicated jelly based on Ibuprofen or Ambroxol. J Therm Anal Calorim 148, 4601–4614 (2023). https://doi.org/10.1007/s10973-023-12052-0

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  • DOI: https://doi.org/10.1007/s10973-023-12052-0

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