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FTIR and thermal studies of medicated jellies with topiramate

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Abstract

Topiramate or (2,3:4,5-bis-O-methylethylidene-β-d-fructopyranose sulfamate) is classified as a sulfamate-substituted monosaccharide derived from fructose and is one of the most efficient antiepileptic drugs. Oral medicated jelly is an easily swallowed dosage form for administration to dysphagic patients including pediatrics or geriatrics. For this study, medicated jellies with topiramate were developed and characterized employing currently used gelling agents: sodium alginate, gelatin and pectin. Moist binary mixtures between topiramate and each component used in jellies were prepared before the jellies formulations to determine the substance compatibility. Topiramate, moist binary mixtures and oral medicated jellies were analyzed by FTIR–UATR spectroscopy, UV–Vis spectroscopy and thermogravimetry to evaluate the thermal behavior and possible interactions between compounds.

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Author notes

  1. Mihaela Maria Budiul and Gabriela Vlase have contributed equally to this work.

Authors and Affiliations

  1. Research Centre for Thermal Analysis in Environmental Problems, West University of Timișoara, Pestalozzi Street 16, 300115, Timisoara, Romania

    Mihaela Maria Budiul, Cristina Adela Marioane, Ionela-Amalia Bradu, Gabriela Vlase & Titus Vlase

  2. ICAM - Advanced Environmental Research Institute, West University of Timisoara, Oituz no. 4, Timisoara, Romania

    Mihaela Maria Budiul, Gabriela Vlase & Titus Vlase

Authors
  1. Mihaela Maria Budiul
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  2. Cristina Adela Marioane
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  3. Ionela-Amalia Bradu
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  4. Gabriela Vlase
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  5. Titus Vlase
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Contributions

GV, TV and MMB contributed to conceptualization; CAM, TV and GV curated data; MMB, IAB and TV contributed to formal analysis; GV, CAM, IAB, MMB and TV contributed to investigation; GV and TV contributed to methodology; TV contributed to software; GV and TV contributed to supervision; TV and MMB contributed to validation; CAM, IAM and TV contributed to visualization; GV, MMB and TV contributed to writing—original draft; GV, TV and MMB contributed to writing—review and editing. All authors have read and agreed to the published version of the manuscript.

Corresponding author

Correspondence to Titus Vlase.

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Budiul, M.M., Marioane, C.A., Bradu, IA. et al. FTIR and thermal studies of medicated jellies with topiramate. J Therm Anal Calorim 148, 4589–4600 (2023). https://doi.org/10.1007/s10973-022-11882-8

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  • DOI: https://doi.org/10.1007/s10973-022-11882-8

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