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Thermochemical analysis of intermolecular interactions of L-carnosine with isonicotinic acid in aqueous solutions

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Abstract

Investigation of the interactions between pyridine derivatives and model compounds of protein, as dipeptides and oligopeptides, is of special interest for pharmaceutical applications. Studies on physicochemical properties of their aqueous solutions play key role in understanding the nature of molecular interactions in liquid mixtures. Here the calorimetric method was used to measure the enthalpy of mixing in aqueous solutions of the dipeptide L-carnosine with the drug isonicotinic acid. The data were analyzed based on the McMillan–Mayer theory to obtain the cross-pair interaction coefficient, hxy, that indicates relatively strong interactions with predominant hydrophilic specific interactions.

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Acknowledgements

The calorimetric measurements were carried out at the Institute of Thermodynamics and Kinetics of Chemical Processes of the Ivanovo State University of Chemistry and Technology (ISUCT) using the equipment of the Centre for Collective Use of ISUCT. The study was carried out with the financial support of the Ministry of Science and Higher Education of the Russian Federation (Project FZZW-2020-0009).

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Authors and Affiliations

  1. Ivanovo State University of Chemistry and Technology, Ivanovo, Russia, 7, Sheremetevskiy av., Ivanovo, 153000, Russia

    O. N. Krutova & T. R. Usacheva

  2. Saint Petersburg State University, Saint Petersburg, Russia

    M. S. Myshenkov

  3. University of Naples Federico II, Naples, Italy

    M. Niccoli & C. Giancola

Authors
  1. O. N. Krutova
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  2. T. R. Usacheva
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  3. M. S. Myshenkov
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  4. M. Niccoli
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  5. C. Giancola
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Correspondence to O. N. Krutova.

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Krutova, O.N., Usacheva, T.R., Myshenkov, M.S. et al. Thermochemical analysis of intermolecular interactions of L-carnosine with isonicotinic acid in aqueous solutions. J Therm Anal Calorim 147, 6461–6467 (2022). https://doi.org/10.1007/s10973-021-10982-1

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  • DOI: https://doi.org/10.1007/s10973-021-10982-1

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