Abstract
The preparation of Calcipotriol by solid lipid nanoparticles and the encapsulation of drugs in solid lipids are expected to obtain a new preparation with strong cutin permeability, slow release and targeting effect, so as to improve the local therapeutic effect of the drug and reduce the occurrence of skin irritation symptoms. In this work, Calcipotriol solid lipid nanoparticle (CPT-SLN) preparation methods are introduced and the stability of CPT-SLNs gel was evaluated by appearance, leakage rate and content. The performance was stable in a low-temperature environment of 4 °C for 40 days. There were no significant changes in appearance, and drug content and permeability can be controlled around 0.00469% and 0.26. However, it has poor stability under the storage conditions of 25 °C and 40 °C at room temperature. Therefore, the suitable conditions for the gel storage should be around 4 °C and sealed away from light. Pharmacodynamic experiments showed that CPT solid lipid nanoparticle gel was more effective than market-sale Calcipotriol ointment in the treatment of psoriasis. Further clinical tests have shown that CPT-SLNS can cure plaque psoriasis more effectively.
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References
Korman NJ. Management of psoriasis as a systemic disease: what is the evidence? Br J Dermatol. 2020;182(4):840–8.
Zhao S, Xie B, Li Y, Zhao XY, Kuang Y, Su J, et al. Smart identification of psoriasis by images using convolutional neural networks: a case study in China. J Eur Acad Dermatol Venereol. 2020;34(3):518–24.
Mason J, Mason AR, Cork MJ. Topical preparations for the treatment of psoriasis: a systematic review. Br J Dermatol. 2000;142(3):351–64.
Sørensen H, Blnderup L, Calverley MJ, Hoffmeyer L, Andersen NR. In vitro metabolism of calcipotriol (MC 903), a vitamin D analogue. Biochem Pharmacol. 1990;39(2):391–3.
Scott LJ, Dunn CJ, Goa KL. Calcipotriol ointment. Am J Clin Dermatol. 2001;2(2):95–120.
Arora R, Katiyar SS, Kushwah V, Jain S. Solid lipid nanoparticles and nanostructured lipid carrier-based nanotherapeutics in treatment of psoriasis: a comparative study. Expert Opin Drug Deliv. 2017;14(2):165–77.
Sonawane R, Harde H, Katariya M, Agrawal S, Jain S. Solid lipid nanoparticles-loaded topical gel containing combination drugs: an approach to offset psoriasis. Expert Opin Drug Deliv. 2014;11(12):1833–47.
Ferreira M, Barreiros L, Segundo MA, Torres T, Selores M, Lima SAC, Reis S. Topical co-delivery of methotrexate and etanercept using lipid nanoparticles: a targeted approach for psoriasis management. Colloids Surf B. 2017;159:23–9.
Agrawal U, Gupta M, Vyas SP. Capsaicin delivery into the skin with lipidic nanoparticles for the treatment of psoriasis. Artif Cells Nanomed Biotechnol. 2015;43(1):33–9.
Fang JY, Fang CL, Liu CH, Su YH. Lipid nanoparticles as vehicles for topical psoralen delivery: solid lipid nanoparticles (SLN) versus nanostructured lipid carriers (NLC). Eur J Pharm Biopharm. 2008;70(2):633–40.
Garcês A, Amaral MH, Lobo JS, Silva AC. Formulations based on solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for cutaneous use: a review. Eur J Pharm Sci. 2018;112:159–67.
Pradhan M, Alexander A, Singh MR, Singh D, Saraf S, Saraf S. Understanding the prospective of nano-formulations towards the treatment of psoriasis. Biomed Pharmacother. 2018;107:447–63.
Liu MM. Study on the formulations of solid lipid nanoparticles for Calciporitol. Doctoral dissertation, Nanchang University, China. 2011.
Li LN. The preparation of FK506-SLN hydrogel and its transdermal and pharmacodynamics studies. Doctoral dissertation, Southern Medical University, China. 2012.
Li Y, Moradi I, Kalantar M, Babadi E, Malekahmadi O, Mosavi A. Synthesis of new dihybrid nanofluid of TiO2/MWCNT in water–ethylene glycol to improve mixture thermal performance: preparation, characterization, and a novel correlation via ANN based on orthogonal distance regression algorithm. J Thermal Anal Calorim. 2020. https://doi.org/10.1007/s10973-020-10392-9.
Sun C, Taherifar S, Malekahmadi O, Karimipour A, Karimipour A, Bach QV. Liquid paraffin thermal conductivity with additives tungsten trioxide nanoparticles: synthesis and propose a new composed approach of fuzzy logic/artificial neural network. Arab J Sci Eng. 2021. https://doi.org/10.1007/s13369-020-05151-9.
Alsarraf J, Malekahmadi O, Karimipour A, Tlili I, Karimipour A, Ghashang M. Increase thermal conductivity of aqueous mixture by additives graphene nanoparticles in water via an experimental/numerical study: synthesise, characterization, conductivity measurement, and neural network modeling. Int Commun Heat Mass Transfer. 2020;118:104864.
Lin CP, Wu YC, Lin ZW, Tsai SY (2020) Assessment of the thermal and oxidative stability of Antrodia salmonea extract in dripping pills via DSC and TAM air analyses. J Thermal Anal Calorim. https://doi.org/10.1007/s10973-020-10397-4
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Ren, G., Zhao, Y. Preparation methods and thermal stability of calcipotriol solid lipid nanoparticles and efficacy in plaque psoriasis treatment. J Therm Anal Calorim 144, 2091–2098 (2021). https://doi.org/10.1007/s10973-021-10627-3
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DOI: https://doi.org/10.1007/s10973-021-10627-3