Skip to main content
SpringerLink
Log in

Preparation methods and thermal stability of calcipotriol solid lipid nanoparticles and efficacy in plaque psoriasis treatment

  • Published:
Journal of Thermal Analysis and Calorimetry Aims and scope Submit manuscript

Abstract

The preparation of Calcipotriol by solid lipid nanoparticles and the encapsulation of drugs in solid lipids are expected to obtain a new preparation with strong cutin permeability, slow release and targeting effect, so as to improve the local therapeutic effect of the drug and reduce the occurrence of skin irritation symptoms. In this work, Calcipotriol solid lipid nanoparticle (CPT-SLN) preparation methods are introduced and the stability of CPT-SLNs gel was evaluated by appearance, leakage rate and content. The performance was stable in a low-temperature environment of 4 °C for 40 days. There were no significant changes in appearance, and drug content and permeability can be controlled around 0.00469% and 0.26. However, it has poor stability under the storage conditions of 25 °C and 40 °C at room temperature. Therefore, the suitable conditions for the gel storage should be around 4 °C and sealed away from light. Pharmacodynamic experiments showed that CPT solid lipid nanoparticle gel was more effective than market-sale Calcipotriol ointment in the treatment of psoriasis. Further clinical tests have shown that CPT-SLNS can cure plaque psoriasis more effectively.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Korman NJ. Management of psoriasis as a systemic disease: what is the evidence? Br J Dermatol. 2020;182(4):840–8.

    Article  CAS  Google Scholar 

  2. Zhao S, Xie B, Li Y, Zhao XY, Kuang Y, Su J, et al. Smart identification of psoriasis by images using convolutional neural networks: a case study in China. J Eur Acad Dermatol Venereol. 2020;34(3):518–24.

    Article  CAS  Google Scholar 

  3. Mason J, Mason AR, Cork MJ. Topical preparations for the treatment of psoriasis: a systematic review. Br J Dermatol. 2000;142(3):351–64.

    Article  Google Scholar 

  4. Sørensen H, Blnderup L, Calverley MJ, Hoffmeyer L, Andersen NR. In vitro metabolism of calcipotriol (MC 903), a vitamin D analogue. Biochem Pharmacol. 1990;39(2):391–3.

    Article  Google Scholar 

  5. Scott LJ, Dunn CJ, Goa KL. Calcipotriol ointment. Am J Clin Dermatol. 2001;2(2):95–120.

    Article  CAS  Google Scholar 

  6. Arora R, Katiyar SS, Kushwah V, Jain S. Solid lipid nanoparticles and nanostructured lipid carrier-based nanotherapeutics in treatment of psoriasis: a comparative study. Expert Opin Drug Deliv. 2017;14(2):165–77.

    Article  CAS  Google Scholar 

  7. Sonawane R, Harde H, Katariya M, Agrawal S, Jain S. Solid lipid nanoparticles-loaded topical gel containing combination drugs: an approach to offset psoriasis. Expert Opin Drug Deliv. 2014;11(12):1833–47.

    Article  CAS  Google Scholar 

  8. Ferreira M, Barreiros L, Segundo MA, Torres T, Selores M, Lima SAC, Reis S. Topical co-delivery of methotrexate and etanercept using lipid nanoparticles: a targeted approach for psoriasis management. Colloids Surf B. 2017;159:23–9.

    Article  CAS  Google Scholar 

  9. Agrawal U, Gupta M, Vyas SP. Capsaicin delivery into the skin with lipidic nanoparticles for the treatment of psoriasis. Artif Cells Nanomed Biotechnol. 2015;43(1):33–9.

    Article  CAS  Google Scholar 

  10. Fang JY, Fang CL, Liu CH, Su YH. Lipid nanoparticles as vehicles for topical psoralen delivery: solid lipid nanoparticles (SLN) versus nanostructured lipid carriers (NLC). Eur J Pharm Biopharm. 2008;70(2):633–40.

    Article  CAS  Google Scholar 

  11. Garcês A, Amaral MH, Lobo JS, Silva AC. Formulations based on solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for cutaneous use: a review. Eur J Pharm Sci. 2018;112:159–67.

    Article  Google Scholar 

  12. Pradhan M, Alexander A, Singh MR, Singh D, Saraf S, Saraf S. Understanding the prospective of nano-formulations towards the treatment of psoriasis. Biomed Pharmacother. 2018;107:447–63.

    Article  CAS  Google Scholar 

  13. Liu MM. Study on the formulations of solid lipid nanoparticles for Calciporitol. Doctoral dissertation, Nanchang University, China. 2011.

  14. Li LN. The preparation of FK506-SLN hydrogel and its transdermal and pharmacodynamics studies. Doctoral dissertation, Southern Medical University, China. 2012.

  15. Li Y, Moradi I, Kalantar M, Babadi E, Malekahmadi O, Mosavi A. Synthesis of new dihybrid nanofluid of TiO2/MWCNT in water–ethylene glycol to improve mixture thermal performance: preparation, characterization, and a novel correlation via ANN based on orthogonal distance regression algorithm. J Thermal Anal Calorim. 2020. https://doi.org/10.1007/s10973-020-10392-9.

    Article  Google Scholar 

  16. Sun C, Taherifar S, Malekahmadi O, Karimipour A, Karimipour A, Bach QV. Liquid paraffin thermal conductivity with additives tungsten trioxide nanoparticles: synthesis and propose a new composed approach of fuzzy logic/artificial neural network. Arab J Sci Eng. 2021. https://doi.org/10.1007/s13369-020-05151-9.

    Article  Google Scholar 

  17. Alsarraf J, Malekahmadi O, Karimipour A, Tlili I, Karimipour A, Ghashang M. Increase thermal conductivity of aqueous mixture by additives graphene nanoparticles in water via an experimental/numerical study: synthesise, characterization, conductivity measurement, and neural network modeling. Int Commun Heat Mass Transfer. 2020;118:104864.

    Article  CAS  Google Scholar 

  18. Lin CP, Wu YC, Lin ZW, Tsai SY (2020) Assessment of the thermal and oxidative stability of Antrodia salmonea extract in dripping pills via DSC and TAM air analyses. J Thermal Anal Calorim. https://doi.org/10.1007/s10973-020-10397-4

Download references

Author information

Authors and Affiliations

  1. Department of Dermatology, Heze Municipal Hospital, Heze, 274000, China

    Guohua Ren & Ying Zhao

Authors
  1. Guohua Ren
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ying Zhao
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ying Zhao.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ren, G., Zhao, Y. Preparation methods and thermal stability of calcipotriol solid lipid nanoparticles and efficacy in plaque psoriasis treatment. J Therm Anal Calorim 144, 2091–2098 (2021). https://doi.org/10.1007/s10973-021-10627-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10973-021-10627-3

Keywords

Search

Navigation