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Insight on spectral, thermal and biological behaviour of some Cu(II) complexes with saturated pentaazamacrocyclic ligands bearing amino acid residues

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Abstract

A novel series of Cu(II) complexes with formula M(HLn)(ClO4)2·mH2O [HLn: 13-membered pentaazamacrocyclic ligand resulted from condensation of N,N′-bis(2-aminoethyl)ethane-1,2-diamine, l-tyrosine (HL1)/l-tryptophan (HL2)/l-phenylalanine (HL3) and formaldehyde] were synthesized by one-pot method. Techniques such as ESI–MS, IR, UV–Vis and EPR spectroscopy provided data characterizing the complexes as mononuclear species. The course of thermal decomposition was followed using TG/DSC–MS analysis in air atmosphere. The TG curves showed a gradual decomposition in several stages that comprise dehydration, decomposition of perchlorate ions as well as fragmentation and oxidative degradation of the organic part. The intermediates formed after first stage of water elimination are stable on 40, 15 and 80 °C interval for complexes (1), (2) and (3), respectively. The compounds were tested on the eukaryotic unicellular organism Saccharomyces cerevisiae, showing variable actions in terms of toxicity, cellular uptake and capacity to alleviate growth defects associated with Cu, Zn-superoxide dismutase (SOD1) depletion.

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Acknowledgements

Slovenian authors would like to thank the Slovenian Research Agency—Slovenia (ARRS) for foundation by Programme P1-0134.

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Authors and Affiliations

  1. Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Str., 050663, Bucharest, Romania

    Elena Pătraşcu, Mihaela Badea & Rodica Olar

  2. Faculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, 1000, Ljubljana, Slovenia

    Nataša Čelan Korošin & Romana Cerc Korošec

  3. Department of Organic Chemistry, Biochemistry and Catalysis, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Str., 050663, Bucharest, Romania

    Lavinia L. Ruţă & Ileana C. Farcaşanu

  4. National Institute of Materials Physics, 077125, Măgurele, Ilfov, Romania

    Maria Nicoleta Grecu

  5. Institut de Chimie Organique et Analytique (ICOA), Université d’Orléans, UMR-CNRS 7311, Rue de Chartres, 45067, Orléans Cedex 2, France

    Gérald Guillaumet

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Pătraşcu, E., Badea, M., Čelan Korošin, N. et al. Insight on spectral, thermal and biological behaviour of some Cu(II) complexes with saturated pentaazamacrocyclic ligands bearing amino acid residues. J Therm Anal Calorim 143, 173–184 (2021). https://doi.org/10.1007/s10973-020-09259-w

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