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Ibuprofen isobutanolammonium salt

Synthesis, thermal analysis, PXRD, FTIR and solubility investigations

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Abstract

Salts of active pharmaceutical ingredients are prepared in order to improve the solubility and bioavailability of the parent drug. In this study, we present the synthesis and characterization of ibuprofen isobutanolammonium salt. Analysis of the synthesized salt was carried out by thermal methods such as differential scanning calorimetry (DSC), thermogravimetry as well as other methods like Fourier transform infrared spectroscopy and powder X-ray diffraction. The DSC curves of the parent drug ibuprofen and its isobutanolammonium salt were found to be different, indicating that a chemical reaction had taken place between the drug and the salt former (2-amino-2-methyl-propan-1-ol). Powder X-ray study analysis also indicated that the product obtained from the reaction was a salt and not a co-crystal of ibuprofen. Solubility analysis of the salt was also performed and clearly showed that salt formation of ibuprofen improved its solubility.

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  1. Institute of Chemical Technology, Mumbai, India

    Reyniel B. Carvalho & Shreerang V. Joshi

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  1. Reyniel B. Carvalho
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  2. Shreerang V. Joshi
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Correspondence to Shreerang V. Joshi.

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Carvalho, R.B., Joshi, S.V. Ibuprofen isobutanolammonium salt. J Therm Anal Calorim 139, 1971–1976 (2020). https://doi.org/10.1007/s10973-019-08572-3

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  • DOI: https://doi.org/10.1007/s10973-019-08572-3

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