Journal of Thermal Analysis and Calorimetry

, Volume 132, Issue 2, pp 1095–1103 | Cite as

Physico-chemical study of norfloxacin and metronidazole binary mixtures

  • Daniela-Crina Salceanu
  • Elena Pincu
  • Giovanna Bruni
  • Amedeo Marini
  • Viorica Meltzer


The physico-chemical characterization of norfloxacin commercial sample (NF), norfloxacin anhydrous form A (NFanhA), norfloxacin pentahydrate (NF·5H2O) and metronidazole (MZ) has been carried out. It was determined that the commercial sample is a mixture of 74% anhydrous NF form A and 26% hemipentahydrate NF. From XRPD analysis, it was observed that after the water loss, NF·5H2O undergoes a solid–solid transition and is converting to NFanhA. Solid–liquid equilibrium for NFanhA–MZ and NF·5H2O–MZ binary systems has been investigated using differential scanning calorimetry, and simple eutectic point was observed, in good approximation, at 419 K for all the mixtures studied. The experimental solid–liquid phase diagram was compared with predictions obtained from available eutectic equilibrium models. The results indicate non-ideality for the mixture. The mixing enthalpy was determined at the eutectic composition and the negative value obtained, ΔMH = − 13.28 kJ mol−1, indicates that molecules of the two components form clusters in the eutectic melt.


Norfloxacin Metronidazole Phase equilibrium Eutectic Combined medicine 



This work was possible with the financial support of the Sectoral Operational Programme for Human Resources Development 2007–2013, co-financed by the European Social Fund, under the Project Number POSDRU/107/1.5/S/80765.


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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2018

Authors and Affiliations

  • Daniela-Crina Salceanu
    • 1
  • Elena Pincu
    • 1
  • Giovanna Bruni
    • 2
  • Amedeo Marini
    • 2
  • Viorica Meltzer
    • 1
  1. 1.Department of Physical Chemistry, Faculty of ChemistryUniversity of BucharestBucharestRomania
  2. 2.Department of Chemistry, Section of Physical Chemistry, C.S.G.IUniversity of PaviaPaviaItaly

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