Advertisement

Journal of Thermal Analysis and Calorimetry

, Volume 133, Issue 1, pp 633–639 | Cite as

Evaluation of compatibility between dried extracts of Myracrodruon urundeuva Allemão and pharmaceutical excipients by TG and DTA

  • Renata da Silva Leite
  • Valmir Gomes de Souza
  • Islaine de Souza Salvador
  • Agna Hélia de Oliveira
  • Antônio de Lima Neto
  • Ionaldo José Lima Diniz Basílio
  • Cícero Flávio Soares Aragão
  • Rui Oliveira Macedo
  • Fábio Santos de Souza
Article

Abstract

Thermoanalytical techniques have been applied in studies of herbal products. Myracrodruon urundeuva Allemão (Anacardiaceae) is a native of Brazil with medicinal properties. This study aimed to characterize the dry extracts of M. urundeuva Allemão and to assess the compatibility of extracts with pharmaceutical excipients in physical mixtures using thermogravimetry (TG) and differential thermal analysis (DTA). The TG curve of M. urundeuva dry extract (ES) showed the occurrence of four mass loss events. The most significant mass loss of extract was observed between 193.5 and 267.0 °C with a loss of 29.7%. The DTA curve showed the endothermic nature of this event with a peak at 235.8 °C (ΔH = 568.5 J g−1). This event is associated with the thermal decomposition of carbohydrates and other organic compounds present in the plant. The SEM image showed the particles of dry extract with spherical shapes, irregular sizes and rough surfaces. SEM analysis of physical mixtures showed that extract dry particles maintained their spherical morphology and appeared uniformly dispersed in the excipient particles. The TG and DTA curves showed no thermal incompatibility between the ES and the excipients lactose, cellulose and starch, but indicated a possible interaction with maltodextrin.

Keywords

Myracrodruon urundeuva Allemão Dry extract TG DTA Spray dryer SEM 

Notes

Acknowledgements

The authors acknowledge the fellowships received from Conselho Nacional de Pesquisa (CNPq).

References

  1. 1.
    Lorenzi H, Matos FJA. Plantas medicinais no Brasil–nativas e exóticas. São Paulo: Nova Odessa, Instituto Plantarum; 2002.Google Scholar
  2. 2.
    Santin DA, Leitão Filho HF. Restabelecimento e revisão taxonômica do gênero Myracrodruon Freire Allemão (Anacardiaceae). Braz J Bot. 1991;14:133–45.Google Scholar
  3. 3.
    Carlini EA, Duarte-Almeida JM, Rodrigues E, Tabach R. Antiulcer effect of the pepper trees Schinus terebinthifolius Raddi (aroeira-da-praia) and Myracrodruon urundeuva Allemão, Anacardiaceae (aroeira-do-sertão). Braz J Pharmacogn. 2010;20(2):140–6.CrossRefGoogle Scholar
  4. 4.
    Souza SMC, Aquino LCM, AC M Jr, Bandeira MAM, Nobre MEP, Viana GSB. Antiinflammatory and antiulcer properties of tannins from Myracrodruon urundeuva Allemão (Anacardiaceae) in Rodents. Phytother Res. 2007;21:220–5.CrossRefGoogle Scholar
  5. 5.
    Rao VS, Viana GS, Menezes AMS, Gadelha MG. Studies on the antiulcerogenic activity of Astronium urundeuva Engl. II. aqueous extract. Braz J Med Biol Res. 1987;20(6):803–5.Google Scholar
  6. 6.
    Viana GSB, Bandeira MAM, Moura LC, Souza Filho MVP, Matos FJA, Ribeiro RA. Analgesic and antiinflammatory effects of the tannin fraction from Myracrodruon urundeuva Fr. All. Phitoter Res. 1997;11:118–22.CrossRefGoogle Scholar
  7. 7.
    Sá RA, Argolo ACC, Napoleão TH, Gomes FS, Santos NDL, Melo CML, Albuquerque AC, Xavier HS, Coelho LCBB, Bieber LW, Paiva PMG. Antioxidant, Fusarium growth inhibition and Nasutitermes corniger repellent activities of secondary metabolites from Myracrodruon urundeuva heartwood. Int Biodeter Biodegr. 2009;63:470–7.CrossRefGoogle Scholar
  8. 8.
    Calou I, Bandeira MA, Aguiar-Galvão W, Cerqueira G, Siqueira R, Neves KR, Brito GA, Viana G. Neuroprotective properties of a standardized extract from Myracrodruon urundeuva Fr. All. (Aroeira-Do-Sertão), as evaluated by a Parkinson’s disease model in rats. Park Dis. 2014;11p.Google Scholar
  9. 9.
    Nobre-Júnior HV, Oliveira RA, Maia FD, Nogueira MAS, Moraes MO, Bandeira MAM, Andrade GM, Viana GSB. Neuroprotective effects of chalcones from Myracrodruon urundeuva on 6-Hydroxydopamine-Induced cytotoxicity in rat mesencephalic cells. Neurochem Res. 2009;34:1066–75.CrossRefGoogle Scholar
  10. 10.
    Mahmoud TS, Marques MR, Pessoa CÓ, Lotufo LVC, Magalhães HIF, Moraes MO, Lima DP, Tininis AG, Oliveira JE. In vitro cytotoxic activity of Brazilian middle west plant extracts. Braz J Pharmacogn. 2011;21(3):456–64.CrossRefGoogle Scholar
  11. 11.
    Carvalho ACB, Balbino EE, Maciel A, Perfeito JPS. Situação do registro de medicamentos fitoterápicos no Brasil. Braz J Pharmacogn. 2008;18:314–9.CrossRefGoogle Scholar
  12. 12.
    Oliveira OW, Petrovick PR. Secagem por aspersão (spray drying) de extratos vegetais: bases e aplicações. Braz J Pharmacogn. 2010;20(4):641–50.CrossRefGoogle Scholar
  13. 13.
    Gallo L, Llabot JM, Allemandi D, Bucalá V, Piña J. Influence of spray-drying operating conditions on Rhamnus purshiana (Cáscara sagrada) extract powder physical properties. Powder Technol. 2011;208(1):205–14.CrossRefGoogle Scholar
  14. 14.
    Cunha AM, Menon S, Menon R, Couto AG, Bürger C, Biavatti MW. Hypoglycemic activity of dried extracts of Bauhinia forficata Link. Phytomed. 2010;17(1):37–41.CrossRefGoogle Scholar
  15. 15.
    Teixeira HF. Avaliação da influência de adjuvantes farmacêuticos sobre as características físicas, químicas, tecnológicas e farmacológicas de extratos secos nebulizados de Achyrocline satureioides (Lam.) DC. Compositae—Marcela. Cader Farm. 1997;13(2):151–2.Google Scholar
  16. 16.
    Broadhead J, Rouan SKE, Rhodes CT. The spray drying of pharmaceuticals. Drug Develop Ind Pharm. 1992;18(11–12):1169–206.CrossRefGoogle Scholar
  17. 17.
    Leite RS, Macedo RO, Torres SM, Batista CCN, Baltazar LDO, Neto SAL, Souza FS. Evaluation of thermal stability and parameters of dissolution of nifedipine crystals. J Therm Anal Calorim. 2013;111(3):2117–23.CrossRefGoogle Scholar
  18. 18.
    Alves MSM, Mendes PC, Jardim MAG, Vieira JGP, Costa RMR, Barbosa WLR, Silva Junior JOC. Physicochemical and phytochemical of Arrabidaea chica (h & b) verlot. Leaf power and standardized tincture. Acta farm bonaerense. 2011;30:804–8.Google Scholar
  19. 19.
    Aragão CFS, Sousa FS, Barros ACS, Veras JWE, Barbosa Filho JM, Macedo RO. Aplicação da termogravimetria (TG) no controle de qualidade da milona (Cissampelos sympodialis Eichl) Menispermaceae. Braz J Pharmacogn. 2002;12:60–1.CrossRefGoogle Scholar
  20. 20.
    Sampaio RCA, Costa RS, Souza CRF, Júnior APD, Ribeiro-Costa RM, Costa CEF, Oliveira WP, Converti A, Silva Júnior JOC. Thermal characterization of Arrabidaea chica (Humb. & Bonpl.) B. Verl. dry extracts obtained by spray dryer. J Therm Anal Calorim. 2016;123:2469–75.CrossRefGoogle Scholar
  21. 21.
    Medeiros ACD, Medeiros IA, Macedo RO. Thermal studies of Albizia inopinata crude extract in the presence of cyclodextrin and Aerosil by TG and DSC coupled to the photovisual system. Thermochim Acta. 2002;392–393:93–8.CrossRefGoogle Scholar
  22. 22.
    Pereira CA, Schnitzler E, Carvalho-Filho MASE. Estudo termoanalitico (TG, DTG, e DSC) dos cafes in natura e processados. Publ. UEPG Ci. Exatas Terra, Ci Agr Eng. 2005;11(1):61–6.Google Scholar
  23. 23.
    Costa RS, Negrão CAB, Camelo SRP, Ribeiro-Costa RM, Barbosa WLR, Costa CEF, Silva Junior JOS. Investigation of thermal behavior of Heliotropium indicum L. lyophilized extract by TG and DSC. J Therm Anal Calorim. 2015;111:1959–64.CrossRefGoogle Scholar
  24. 24.
    Araújo AAS, Mercuri LP, Seixas SRS, Storpirtis S, Matos JR. Determinação dos teores de umidade e cinzas de amostras comerciais de guaraná utilizando métodos convencionais e análise térmica. Rev Bras Ciênc Farm. 2006;42(2):269–77.Google Scholar
  25. 25.
    Silva MD. Estudo Farmacobotânico de Três Espécies Medicinais da Caatinga em Pernambuco. [Dissertação—Mestrado]. Universidade Federal Rural de Pernambuco. 2008.Google Scholar
  26. 26.
    Monteiro JM, Lins Neto EMDF, Amorim ELCD, Strattmann RR, Araújo EL, Albuquerque UPD. Teor de taninos em três espécies medicinais arbóreas simpátricas da caatinga. Rev Árv. 2005;29(6):999–1005.CrossRefGoogle Scholar
  27. 27.
    Kibbe AH. Pharmaceutical excipients. 3rd ed. London: American Pharmaceutical Association; 2000.Google Scholar
  28. 28.
    Figura LO. The physical modification of lactose and its thermoanalytical identification. Thermochim Acta. 1993;222:187–94.CrossRefGoogle Scholar
  29. 29.
    Mihranyan A, Sven-Borje A, EK R. Sorption of nicotine to Cellulose powders. Eur J Pharm Sci. 2004;6(11):2–12.Google Scholar
  30. 30.
    Uesu NY, Pineda EAG, Hechenleitner AAW. Microcrystalline cellulose from soybean husk: effects of solvents treatments on its properties as acetylsalicylic acid carrier. Int J Pharm. 2000;206:85–96.CrossRefGoogle Scholar
  31. 31.
    Verma RK, Garg S. Selection of excipients for extended release formulations of glipizide through drug-excipient compatibility testing. J Pharm Bio Anal. 2005;38:633–44.CrossRefGoogle Scholar
  32. 32.
    Pinto VZ, Vanier NL, Klein B, Zavareze ER, Elias MC, Gutkoski LC, et al. Physicochemical, crystallinity, pasting and thermal properties of heat-moisture-treated pinhão starch. Starch/Starke. 2012;64(11):855–63.CrossRefGoogle Scholar
  33. 33.
    Ford JL, Timmins P. Pharmaceutical thermal analysis. Chichester: Ellis Horwood; 1989.Google Scholar
  34. 34.
    Descamps N, Palzer S, Zuercher U. The amorphous state of spray-dried maltodextrin: sub–sub-Tg enthalpy relaxation and impact of temperature and water annealing. Carbohydr Res. 2009;344(1):85–90.CrossRefGoogle Scholar
  35. 35.
    Osorio C, Forero DP, Carriazo JG. Characterisation and performance assessment of guava (Psidium guajava L.) microencapsulates obtained by spray-drying. Food Res Int. 2011;44(5):1174–81.CrossRefGoogle Scholar
  36. 36.
    Osorio C, Acevedo B, Hillebrand S, Carriazo J, Winterhalter P, Morales AL. Microencapsulation by spray-drying of anthocyanin pigments from corozo (Bactris guineensis) fruit. J Agr Food Chem. 2010;58:6977–85.CrossRefGoogle Scholar
  37. 37.
    Fernandes FHA, Santana CP, Santos RL, Correia LP, Conceição MM, Macedo RO, Medeiros ACD. Thermal characterization of dried extract of medicinal plant by DSC and analytical techniques. J Therm Anal Calorim. 2013;113:443–7.CrossRefGoogle Scholar

Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2017

Authors and Affiliations

  • Renata da Silva Leite
    • 1
  • Valmir Gomes de Souza
    • 2
  • Islaine de Souza Salvador
    • 2
  • Agna Hélia de Oliveira
    • 2
  • Antônio de Lima Neto
    • 2
  • Ionaldo José Lima Diniz Basílio
    • 2
  • Cícero Flávio Soares Aragão
    • 3
  • Rui Oliveira Macedo
    • 1
    • 2
  • Fábio Santos de Souza
    • 1
    • 2
  1. 1.Departamento de Ciências FarmacêuticasUniversidade Federal de Pernambuco, UFPERecifeBrazil
  2. 2.Laboratórios Unificados de Desenvolvimento e Ensaios de Medicamentos, LUDEMUniversidade Federal da Paraíba, UFPBJoão PessoaBrazil
  3. 3.Programa de Pós-graduação em Ciências FarmacêuticasUniversidade Federal do Rio Grande do NorteNatalBrazil

Personalised recommendations